Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Jessenya MilDepartment of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, United States.ORCID 0000-0002-3040-0211
Jose A SotoDepartment of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, United States.ORCID 0000-0002-2246-8961
Nedas MatulionisDepartment of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, United States.ORCID 0000-0001-7624-3090
Abigail KrallDepartment of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, United States.
Francesca DayDepartment of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, United States.
Linsey StilesDepartment of Medicine, Endocrinology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.ORCID 0000-0002-1514-458X
Katrina P MontalesDepartment of Medicine, Endocrinology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.ORCID 0009-0001-4260-2902
Daria J AzizadDepartment of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, United States.ORCID 0009-0006-7015-9027
Carlos E GonzalezDepartment of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, United States.
Patricia R NanoDepartment of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, United States.ORCID 0000-0002-5507-2656
Antoni A MartijaDepartment of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, United States.ORCID 0000-0003-4293-6002
Cesar A Perez-RamirezDepartment of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, United States.
Claudia V NguyenDepartment of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, United States.ORCID 0000-0002-4796-6182
Ryan L KanDepartment of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, United States.ORCID 0000-0003-1162-8365
Madeline G AndrewsSchool of Biological and Health Systems Engineering, Arizona State University, Phoenix, AZ, United States.ORCID 0000-0002-5154-5081
Heather R ChristofkDepartment of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, United States.ORCID 0000-0002-8662-4425
Aparna BhaduriDepartment of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, United States.ORCID 0000-0003-4625-6899
Funding
A Multidisciplinary Center for Developing Human and Non-human Primate Brain Cell AtlasesUM1MH130991 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Hao Huang, ARNOLD KRIEGSTEIN · 2022 to 2026
$25.2M
UCLA SPORE in Brain CancerP50CA211015 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Yvonne Yu-Hsuan Chen · 2017 to 2026
$25.2M
Training Grant in Neurobehavioral GeneticsT32NS048004 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEARDEN, CARRIE E, OPHOFF, ROEL A · 2004 to 2025
$5.8M
Research Training in Cell and Molecular BiologyT32GM145388 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Jorge Torres · 2022 to 2026
$5.2M
Nutrient Regulation of Cancer Cell GrowthR01CA215185 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Heather Christofk · 2018 to 2026
$4.3M
Elucidating Regulation of Cell Fate Specification in Human Cortical Development to Understand Etiology of Neurodevelopment DisordersR01MH132689 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Aparna Bhaduri · 2024 to 2026
$2.1M
Understanding Brain Development Through the Lens of MetabolismR00NS111731 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BHADURI, APARNA · 2021 to 2023
Characterization of cell type emergence during human cortical development, which enables unique human cognition, has focused primarily on anatomical and transcriptional characterizations. Metabolic processes in the human brain that allow for rapid expansion, but contribute to vulnerability to neurodevelopmental disorders, remain largely unexplored. We performed a variety of metabolic assays in primary tissue and stem cell derived cortical organoids and observed dynamic changes in core metabolic functions, including an unexpected increase in glycolysis during late neurogenesis. By depleting glucose levels in cortical organoids, we increased outer radial glia, astrocytes, and inhibitory neurons. We found the pentose phosphate pathway (PPP) was impacted in these experiments and leveraged pharmacological and genetic manipulations to recapitulate these radial glia cell fate changes. These data identify a new role for the PPP in modulating radial glia cell fate specification and generate a resource for future exploration of additional metabolic pathways in human cortical development.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Metabolic Atlas of Early Human Cortex Identifies Regulators of Cell Fate Transitions. · full record | OpenQuestion