Evidence map›Paper›PMID 40161639›Full record

ArticlebioRxiv : the preprint server for biology2025

Temporal Dynamics of the Vaginal Microbiome and Host Immune Markers Before, During, and After Metronidazole Treatment for Bacterial Vaginosis.

Amanda Williams, Jacques Ravel, Rupert Kaul, Eric Armstrong, Sanja Huibner, Johanna B Holm

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Amanda WilliamsCenter for Advanced Microbiome Research and Innovation, Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-1343-1101
Jacques RavelCenter for Advanced Microbiome Research and Innovation, Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-0851-2233
Rupert KaulDepartment of Medicine, University of Toronto; Toronto, Canada.ORCID 0000-0002-1586-4093
Eric ArmstrongDepartment of Medicine, University of Toronto; Toronto, Canada.ORCID 0000-0002-4530-6631
Sanja HuibnerDepartment of Medicine, University of Toronto; Toronto, Canada.
Johanna B HolmCenter for Advanced Microbiome Research and Innovation, Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-7646-4085

Funding

The Microbial Ecology of Bacterial Vaginosis: A Fine Scale Resolution MetagenomicUH2AI083264 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI RAVEL, JACQUES · 2009 to 2011
$1.9M
Systems-Level Research in Microbial PathogenesisT32AI162579 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI NICHOLAS H CARBONETTI, Julie Dunning Hotopp · 2022 to 2026
$1.7M
Integrating multi-omics data: Modeling biomarkers and mechanisms to reduce bacterial vaginosis recurrenceK01AI163413 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI HOLM, JOHANNA B. · 2021 to 2025
$464k
NIAID NIH HHS K01 AI163413NIAID NIH HHS T32 AI162579NIAID NIH HHS UH2 AI083264
6 · The paper itself

Abstract

This study analyzed metagenomic and immune marker profiles of seven individuals before, during, and after a 7-day course of metronidazole treatment for bacterial vaginosis (BV). Treatment reduced BV-associated bacteria and immune marker levels, with distinct early (days 1-4) and late (days 5-7) phases. Post-treatment, variability in microbial and immune marker profiles demonstrated a rapid resurgence of certain BV associated bacteria, highlighting the need for additional strategies like probiotics to maintain a healthy vaginal microbiome. The study found significant host and microbial influences on immune response variance, with IP-10 and sEcad highly correlated with the vaginal microbiome. The findings identify optimal timing for administering live biotherapeutics to restore D-lactic acid-producing

Indexed as

antibioticsinflammatory markersmetagenomevaginal dysbiosisvaginal microbiota

Identifiers

PMID40161639
PMCPMC11952498

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.