Evidence map›Paper›PMID 40161621›Full record

ArticlebioRxiv : the preprint server for biology2025

Uncovering synaptic and cellular nanoarchitecture of brain tissue via seamless

Jiying Ning, Jill R Glausier, Rangana Warshamanage, Leslie Gunther-Cummins, Tom Burnley, Colin M Palmer, Guillermo Gonzalez-Burgos, Takeaki Miyamae, Jing Wang, Diane Carlisle and 12 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Jiying NingDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0002-8244-7230
Jill R GlausierDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0001-9838-3414
Rangana WarshamanageScientific Computing Department, Science and Technology Facilities Council, Research Complex at Harwell, Didcot OX11 0FA, UK.ORCID 0000-0001-9756-0001
Leslie Gunther-CumminsAnalytical Imaging Facility, Albert Einstein College of Medicine, Bronx, NY 10461, USA.ORCID 0000-0002-9652-5578
Tom BurnleyScientific Computing Department, Science and Technology Facilities Council, Research Complex at Harwell, Didcot OX11 0FA, UK.ORCID 0000-0001-5307-348X
Colin M PalmerScientific Computing Department, Science and Technology Facilities Council, Research Complex at Harwell, Didcot OX11 0FA, UK.ORCID 0000-0002-4883-1546
Guillermo Gonzalez-BurgosDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0002-1650-8111
Takeaki MiyamaeDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0001-8917-9542
Jing WangThermo Fisher Scientific, 5350 NE Dawson Creek Drive, Hillsboro, OR, 97124, USA.
Diane CarlisleDepartment of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.ORCID 0000-0002-6455-6337
Chyongere HsiehWadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY 12201, USA.
Thomas SchmelzerTGS Technologies, LLC, Cranberry Township, PA 16066, USA.
Silas A BuckDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0002-9476-9210
Jonathan FranksDepartment of Cell Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0002-5758-185X
Cheri M HamptonMaterials and Manufacturing Directorate, Air Force Research Laboratory, Wright-Patterson Air Force Base, Dayton, OH, 45433, USA.ORCID 0000-0003-0069-8712
William R StaufferCenter for Neuroscience, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0003-1031-8824
David A LewisDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Robert M FriedlanderDepartment of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.ORCID 0000-0003-4423-9219
Frank P MacalusoAnalytical Imaging Facility, Albert Einstein College of Medicine, Bronx, NY 10461, USA.ORCID 0000-0002-5321-6118
Martyn WinnScientific Computing Department, Science and Technology Facilities Council, Research Complex at Harwell, Didcot OX11 0FA, UK.ORCID 0000-0003-0496-6796
Michael MarkoWadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY 12201, USA.
Zachary FreybergDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0001-6460-0118

Funding

WORD PROCESSORP30CA013330 · NCI · YESHIVA UNIVERSITY · PI Ulrich Steidl · 1985 to 2026
$111.2M
National Research Mentoring Network for a Diverse Biomedical WorkforceU54GM119023 · NIGMS · BOSTON COLLEGE · PI OFILI, ELIZABETH O., OKUYEMI, KOLAWOLE S · 2015 to 2018
$15.3M
Ultra-fast high-resolution imaging of whole mouse brain for the study of drug addictionR21DA052419 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FREYBERG, ZACHARY, LOGAN, RYAN W · 2021 to 2022
$448k
A novel role for midbrain glutamate co-transmitting neurons in alcohol drinking and motivated behaviorsR21AA028800 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FREYBERG, ZACHARY, LOGAN, RYAN W · 2021 to 2022
$446k
Mechanisms for Preserving Neurons in Alzheimer's Disease-Related Dementias Across Drosophila and Mouse ModelsR21AG068607 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FREYBERG, ZACHARY · 2020 to 2021
$430k
NCI NIH HHS P30 CA013330NIAAA NIH HHS R21 AA028800NIA NIH HHS R21 AG068607NIDA NIH HHS R21 DA052419NIGMS NIH HHS U54 GM119023
6 · The paper itself

Abstract

Cell-cell communication underlies all emergent properties of the brain, including cognition, learning and memory. The physical basis for these communications is the synapse, a multi-component structure requiring coordinated interactions between diverse cell types. However, many aspects of three-dimensional (3D) synaptic organization remain poorly understood. Here, we developed an approach, seamless

Indexed as

brain tissueCryo-electron tomographyHuntington’s diseasemitochondriasynapsesynaptic vesicles

Identifiers

PMID40161621
PMCPMC11952431

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.