Evidence map›Paper›PMID 40161617›Full record

ArticlebioRxiv : the preprint server for biology2025

Environmental NaCl affects

Franziska Pohl, Brian M Egan, Daniel L Schneider, Matthew C Mosley, Micklaus A Garcia, Sydney Hou, Chen-Hao Chiu, Kerry Kornfeld

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Franziska PohlDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0001-9979-1268
Brian M EganDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0003-3770-5605
Daniel L SchneiderDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0001-9408-8901
Matthew C MosleyDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-2181-923X
Micklaus A GarciaDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0001-7046-4386
Sydney HouDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Chen-Hao ChiuDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0003-3524-792X
Kerry KornfeldDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-6042-5241

Funding

TRAINING PROGRAM IN CELLULAR AND MOLECULAR BIOLOGYT32GM007067 · NIGMS · WASHINGTON UNIVERSITY · PI TRUE-KROB, HEATHER L · 1985 to 2020
$20.4M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
DISCOVER DETERMINANTS OF INDIVIDUAL LIFESPAN AND HEALTHR01AG057748 · NIA · WASHINGTON UNIVERSITY · PI KORNFELD, KERRY · 2019 to 2023
$2.1M
Using Optogenetics to Dissect the Role of Redox Signaling During C. Elegans AgingR21AG058037 · NIA · WASHINGTON UNIVERSITY · PI HELD, JASON M., KORNFELD, KERRY · 2018 to 2020
$479k
Control of reproductive aging by germline stem cellsR56AG072169 · NIA · WASHINGTON UNIVERSITY · PI KORNFELD, KERRY · 2021 to 2021
$323k
An IC-ICP-MS for advanced speciation and metalomics analysisS10OD020118 · OD · NORTHWESTERN UNIVERSITY · PI O'HALLORAN, THOMAS V · 2015 to 2015
$268k
NIA NIH HHS R01 AG057748NIA NIH HHS R21 AG058037NIA NIH HHS R56 AG072169NIGMS NIH HHS T32 GM007067NIH HHS P40 OD010440NIH HHS S10 OD020118
6 · The paper itself

Abstract

Sodium is an essential nutrient, but is toxic in excess. In humans, excessive dietary sodium can cause high blood pressure, which contributes to age-related diseases including stroke and heart disease. We used

Indexed as

agingC. elegansdaf-2developmentlifespansaltsodium chloride (NaCl)

Identifiers

PMID40161617
PMCPMC11952357

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.