Evidence map›Paper›PMID 40161598›Full record

ArticlebioRxiv : the preprint server for biology2025

The Kelch 3 motif on gigaxonin mediates the interaction with NUDCD3 and regulates vimentin filament morphology.

Cassandra L Phillips, Christina So, Meredith F Gillis, Jonathan Harrison, Chih-Hsuan Hsu, Diane Armao, Natasha T Snider

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Cassandra L PhillipsDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill.ORCID 0000-0003-3265-1919
Christina SoDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill.
Meredith F GillisDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill.
Jonathan HarrisonDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill.
Chih-Hsuan HsuDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill.
Diane ArmaoDepartment of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill.
Natasha T SniderDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill.

Funding

Enhancement Training for the Next Generation of Translational Ph.D. ScientistsT32GM122741 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WOLBERG, ALISA S., YEH, JEN JEN · 2018 to 2022
$898k
Intermediate Filament Proteostasis and RNA regulation in Giant Axonal NeuropathyR21NS121578 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ARMAO, DIANE, SNIDER, NATASHA T · 2021 to 2022
$428k
American Heart Association-American Stroke Association 24PRE1193707NIGMS NIH HHS T32 GM122741NINDS NIH HHS R21 NS121578
6 · The paper itself

Abstract

Gigaxonin is an intermediate filament (IF)-interacting partner belonging to the Kelch-like (KLHL) protein family. Gigaxonin is encoded by the

Identifiers

PMID40161598
PMCPMC11952450

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.