Evidence map›Paper›PMID 40161577›Full record

ArticlebioRxiv : the preprint server for biology2025

Replicative selfish genetic elements are driving rapid pathogenic adaptation of

Matthew P Grieshop, Aaron A Behr, Sierra Bowden, Jordan D Lin, Marco Molari, Gabriella Zm Reynolds, Erin F Brooks, Boryana Doyle, Guillermo Rodriguez-Nava, Jorge L Salinas and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Matthew P GrieshopDepartment of Genetics, Stanford University, Stanford, CA, USA.ORCID 0000-0002-0075-8597
Aaron A BehrDepartment of Biology, Stanford University, Stanford, CA, USA.ORCID 0000-0001-6660-9546
Sierra BowdenDepartment of Genetics, Stanford University, Stanford, CA, USA.
Jordan D LinDepartment of Medicine, Division of Hematology, Stanford University, Stanford, CA, USA.
Marco MolariSwiss Institute of Bioinformatics, Basel, Switzerland.
Gabriella Zm ReynoldsDepartment of Genetics, Stanford University, Stanford, CA, USA.
Erin F BrooksDepartment of Medicine, Division of Hematology, Stanford University, Stanford, CA, USA.
Boryana DoyleStanford University School of Medicine, Stanford, CA, USA.
Guillermo Rodriguez-NavaDepartment of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA, USA.
Jorge L SalinasDepartment of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA, USA.
Niaz BanaeiDepartment of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA, USA.
Ami S BhattDepartment of Genetics, Stanford University, Stanford, CA, USA.ORCID 0000-0001-8099-2975

Funding

Culture-free pathogen tracking in hospitalized patientsR01AI143757 · NIAID · STANFORD UNIVERSITY · PI BHATT, AMI SIDDHARTH · 2020 to 2023
$3.0M
Emerging novel mechanisms of antibiotic resistance in the prevalent foodborne pathogen, SalmonellaR01AI148623 · NIAID · STANFORD UNIVERSITY · PI BHATT, AMI SIDDHARTH · 2019 to 2023
$2.0M
Computational appliance: a supercomputer for modern biomedical researchS10OD023452 · OD · STANFORD UNIVERSITY · PI DATTA, SOMALEE · 2017 to 2017
$600k
NIAID NIH HHS R01 AI143757NIAID NIH HHS R01 AI148623NIH HHS S10 OD023452
6 · The paper itself

Abstract

Understanding how healthcare-associated pathogens adapt in clinical environments can inform strategies to reduce their burden. Here, we investigate the hypothesis that insertion sequences (IS), prokaryotic transposable elements, are a dominant mediator of rapid genomic evolution in healthcare-associated pathogens. Among 28,207 publicly available pathogen genomes, we find high copy numbers of the replicative ISL3 family in healthcare-associated

Identifiers

PMID40161577
PMCPMC11952509

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.