Evidence map›Paper›PMID 40161550›Full record

ArticleGynecologic oncology reports2025

Oncologic and fertility outcome in patients with advanced stage ovarian immature teratomas.

Marino Giuseppe, Negri Serena, Testa Filippo, Giuliani Daniela, De Ponti Elena, Bombelli Martina, Giorgia Pecis Cavagna, Lugotti Daniele, Jaconi Marta, Casiraghi Alessandra and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gynecologic oncology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Marino GiuseppeDepartment of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
Negri SerenaDepartment of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
Testa FilippoDepartment of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
Giuliani DanielaUO Gynecology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.
De Ponti ElenaMedical Physics Department, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.
Bombelli MartinaDepartment of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
Giorgia Pecis CavagnaDepartment of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
Lugotti DanieleDepartment of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
Jaconi MartaDepartment of Pathology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.
Casiraghi AlessandraDepartment of Radiodiagnostics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.
Bianchi TommasoUO Gynecology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.
Grassi TommasoUO Gynecology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.
Bonazzi Maria CristinaUO Gynecology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.
Fruscio RobertDepartment of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Immature teratomas represent rare malignant ovarian germ cell tumours, typically involving young women Methods: Clinicopathological data were retrospectively collected and analysed from a cohort of 17 post-pubertal patients with advanced stage immature teratomas in a single centre between 1980 and 2024. Results: Among 17 patients included in the study, 76.5 % (13/17) underwent fertility-sparing surgery (FSS) and 23.5 % (4/17) radical surgery. Adjuvant chemotherapy was administered in 82 % (14/17) of patients. After a median follow up of 237 months (range 68.0-289.0), 2 patients had persistent disease after receiving chemotherapy and 3 showed relapse. Of these, two had a second relapse. All patients are alive without evidence of disease at the last follow up. Also 46 % (6/13) of women treated with FSS reached pregnancy. Conclusions: FSS appears to be safe and effective in the treatment of advanced stage immature teratoma. Despite surgical interventions and the administration of chemotherapy in the majority of patients, fertility outcome is satisfactory.

Indexed as

Fertility sparing surgeryGerm cell tumorsImmature teratomasOvary

Identifiers

PMID40161550
PMCPMC11952808

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.