Evidence map›Paper›PMID 40161539›Full record

ArticleNanophotonics (Berlin, Germany)2025

Wavefront correction with image-based interferometric focus sensing in two-photon microscopy.

Ruiwen Yang, Yanlong Yang, Tengfei Wu, Yang Zhang, Dan Dan, Junwei Min, Xianghua Yu, Taiqiang Dai, Liang Kong, Li Li and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanophotonics (Berlin, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ruiwen YangState Key Laboratory of Ultrafast Optical Science and Technology, Xi'an Institute of Optics and Precision Mechanics, Chinese Academy of Sciences, Xi'an 710119, China.ORCID https://orcid.org/0009-0007-3515-8827
Yanlong YangState Key Laboratory of Ultrafast Optical Science and Technology, Xi'an Institute of Optics and Precision Mechanics, Chinese Academy of Sciences, Xi'an 710119, China.ORCID https://orcid.org/0000-0003-3804-7130
Tengfei WuState Key Laboratory of Ultrafast Optical Science and Technology, Xi'an Institute of Optics and Precision Mechanics, Chinese Academy of Sciences, Xi'an 710119, China.
Yang ZhangState Key Laboratory of Ultrafast Optical Science and Technology, Xi'an Institute of Optics and Precision Mechanics, Chinese Academy of Sciences, Xi'an 710119, China.
Dan DanState Key Laboratory of Ultrafast Optical Science and Technology, Xi'an Institute of Optics and Precision Mechanics, Chinese Academy of Sciences, Xi'an 710119, China.
Junwei MinState Key Laboratory of Ultrafast Optical Science and Technology, Xi'an Institute of Optics and Precision Mechanics, Chinese Academy of Sciences, Xi'an 710119, China.
Xianghua YuState Key Laboratory of Ultrafast Optical Science and Technology, Xi'an Institute of Optics and Precision Mechanics, Chinese Academy of Sciences, Xi'an 710119, China.
Taiqiang DaiDepartment of Oral and Maxillofacial Surgery, State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, School of Stomatology, The Fourth Military Medical University, Xi'an 710032, China.
Liang KongDepartment of Oral and Maxillofacial Surgery, State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, School of Stomatology, The Fourth Military Medical University, Xi'an 710032, China.
Li LiDepartment of Ophthalmology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
Baoli YaoState Key Laboratory of Ultrafast Optical Science and Technology, Xi'an Institute of Optics and Precision Mechanics, Chinese Academy of Sciences, Xi'an 710119, China.ORCID https://orcid.org/0000-0002-1723-6680

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adaptive optics is a technology that corrects wavefront distortions to enhance image quality. Interferometric focus sensing (IFS), a relatively recently proposed method within the field of adaptive optics, has demonstrated effectiveness in correcting complex aberrations in deep tissue imaging. This approach determines the correction pattern based on a single location within the sample. In this paper, we propose an image-based interferometric focus sensing (IBIFS) method in a conjugate adaptive optics configuration that progressively estimates and corrects the wavefront over the entire field of view by monitoring the feedback of image quality metrics. The sample conjugate configuration allows for the correction of multiple points across the full field of view by sequentially measuring the correction pattern for each point. We experimentally demonstrate our method on both the fluorescent beads and the mouse brain slices using a custom-built two-photon microscope. We show that our approach has a large effective field of view as well as more stable optimization results compared to the region of interest based method.

Indexed as

adaptive opticsimage-based metricinterferometric focus sensingtwo-photon microscopy

Identifiers

PMID40161539
PMCPMC11953718

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.