Evidence map›Paper›PMID 40161404›Full record

ArticleSleep advances : a journal of the Sleep Research Society2025

Tonic-clonic seizures induce hypersomnia and suppress rapid eye movement sleep in mouse models of epilepsy.

Ruizhi Wang, Sasa Teng, Matt Turanchik, Fenghua Zhen, Yueqing Peng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sleep advances : a journal of the Sleep Research Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ruizhi WangDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Sasa TengDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Matt TuranchikColumbia School of General Studies, Columbia University, New York, NY, USA.
Fenghua ZhenNational Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.
Yueqing PengDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.ORCID https://orcid.org/0000-0002-3488-0670

Funding

Neural Control of NREM Sleep in the MedullaR01NS129997 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Yueqing Peng · 2023 to 2026
$1.6M
Basal forebrain cholinergic dysfunction in sleep-related epilepsyR21NS120027 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PENG, YUEQING · 2020 to 2020
$446k
NINDS NIH HHS R01 NS129997NINDS NIH HHS R21 NS120027
6 · The paper itself

Abstract

The reciprocal relationship between sleep and epilepsy has been reported by numerous clinical studies. However, the underlying neural mechanisms are poorly understood. Animal models of epilepsy are powerful tools to tackle this question. A lagging research area is the understudied sleep in epilepsy models. Here, we characterize sleep architecture and its relationship with seizures in a mouse model of sleep-related hypermotor epilepsy, caused by mutation of

Indexed as

EEGepilepsyKcnt1Sleeptonic-clonic seizures

Identifiers

PMID40161404
PMCPMC11954448

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.