Evidence map›Paper›PMID 40161372›Full record

ArticleFrontiers in oncology2025

Next-generation sequencing guides diagnosis and treatment in a complex presentation of ALK-positive anaplastic large-cell lymphoma: a case report.

Tejasvini Vaid, Thomas S Gunning, Rachel Cohen, Alexandra Della Pia, Jason Voss, Melinda Weber, Andrew L Pecora, Lori A Leslie, Tatyana Feldman, Andre H Goy and 2 more

Abstract readCase Reports
In one paragraph

Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tejasvini Vaid *Department of Medical Oncology and Hematology, Medanta-The Medicity, Gurgaon, India.
Thomas S Gunning *Department of Oncology, Hackensack Meridian School of Medicine, Nutley, NJ, United States.
Rachel CohenAmerican Medical Program, Tel Aviv University, Tel Aviv, Israel.
Alexandra Della PiaJohn Theurer Cancer Center, Hackensack Meridian Health, Hackensack, NJ, United States.
Jason VossJohn Theurer Cancer Center, Hackensack Meridian Health, Hackensack, NJ, United States.
Melinda WeberJohn Theurer Cancer Center, Hackensack Meridian Health, Hackensack, NJ, United States.
Andrew L PecoraDepartment of Oncology, Hackensack Meridian School of Medicine, Nutley, NJ, United States.
Lori A LeslieDepartment of Oncology, Hackensack Meridian School of Medicine, Nutley, NJ, United States.
Tatyana FeldmanDepartment of Oncology, Hackensack Meridian School of Medicine, Nutley, NJ, United States.
Andre H GoyDepartment of Oncology, Hackensack Meridian School of Medicine, Nutley, NJ, United States.
Maher AlbitarGenomic Testing Cooperative, Irvine, CA, United States.
Andrew IpDepartment of Oncology, Hackensack Meridian School of Medicine, Nutley, NJ, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Next-generation sequencing (NGS) technology is being increasingly utilized in the management of cancer patients due to its diagnostic, therapeutic, and prognostic value, and potential to inform use of targeted therapy. We report a case wherein performing NGS testing proved to be a critical component in diagnosis and therapeutic decision making. The case was of a patient who presented with diffuse osteolytic bone lesions that on biopsy showed an undifferentiated malignancy. A diagnosis of poorly differentiated sarcoma was made at an outside institution and carboplatin and paclitaxel was initiated. However, NGS testing revealed a

Indexed as

case reportlymphomanext-generation sequencingNGStargeted therapy

Identifiers

PMID40161372
PMCPMC11949968

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.