Evidence map›Paper›PMID 40161292›Full record

ArticleResuscitation plus2025

Chest compression synchronized ventilation during prolonged experimental cardiopulmonary resuscitation improves oxygenation but may cause pneumothoraces.

Jukka Kopra, Lassi Mehtonen, Merja Laitinen, Erik Litonius, Oiva Arvola, Robert Östman, Juho A Heinonen, Markus B Skrifvars, Pirkka T Pekkarinen

Abstract read
In one paragraph

Article in Resuscitation plus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jukka KopraDepartment of Emergency Care and Services, University of Helsinki and Helsinki University Hospital, Paciuksenkatu 1, 00290 Helsinki, Finland.
Lassi MehtonenUniversity of Latvia, Faculty of Medicine, Jelgavas street 3-330, LV - 1004, Riga, Latvia.
Merja LaitinenVetCT Teleconsulting - Teleradiology Small Animal Team, Helsinki, Finland.
Erik LitoniusDivision of Anaesthesiology, Department of Anaesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Haartmaninkatu 4, 00290 Helsinki, Finland.
Oiva ArvolaDivision of Anaesthesiology, Department of Anaesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Haartmaninkatu 4, 00290 Helsinki, Finland.
Robert ÖstmanDepartment of Emergency Care and Services, University of Helsinki and Helsinki University Hospital, Paciuksenkatu 1, 00290 Helsinki, Finland.
Juho A HeinonenDepartment of Anaesthesiology and Intensive Care Medicine and Centre for Prehospital Emergency Care and Emergency Medicine, Päijät-Häme Central Hospital, Keskussairaalankatu 7, 15850 Lahti, Finland.
Markus B SkrifvarsDivision of Intensive Care, Department of Anaesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Haartmaninkatu 4, 00290 Helsinki, Finland.
Pirkka T PekkarinenDivision of Intensive Care, Department of Anaesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Haartmaninkatu 4, 00290 Helsinki, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Chest compression synchronized ventilation (CCSV) has been proposed to provide superior ventilation and haemodynamics during cardiac arrest (CA) compared to conventional asynchronous ventilation and compressions. We compared arterial gas exchange, pH, lactate levels and haemodynamics between CCSV and manual asynchronous ventilation during prolonged experimental CA. Methods: We randomized 30 pigs (weight ca. 55 kg) to receive CCSV with a MEDUMAT Standard Results: The median intra-arrest arterial blood gas results for CCSV were PaO Conclusions: The CCSV protocol resulted in higher arterial oxygenation but more pneumothoraces.The study was approved by the Finnish National Animal Experiment Board (ESAVI-26974-2023).

Indexed as

Arterial oxygen pressureCardiac arrestComputed tomographyMechanical chest compressionMechanical ventilationVentilation

Identifiers

PMID40161292
PMCPMC11953954

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.