Evidence map›Paper›PMID 40161218›Full record

ArticleBrain communications2025

Mild traumatic brain injury increases cortical iron: evidence from individual susceptibility mapping.

Christi A Essex, Devon K Overson, Jenna L Merenstein, Trong-Kha Truong, David J Madden, Mayan J Bedggood, Catherine Morgan, Helen C Murray, Samantha J Holdsworth, Ashley W Stewart and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Christi A EssexDepartment of Psychology and Neuroscience, Auckland University of Technology, Auckland 0627, New Zealand.ORCID https://orcid.org/0009-0006-8687-3786
Devon K OversonBrain Imaging and Analysis Center, Duke University Medical Center, Durham, NC 27710, USA.
Jenna L MerensteinBrain Imaging and Analysis Center, Duke University Medical Center, Durham, NC 27710, USA.ORCID https://orcid.org/0000-0003-1631-1340
Trong-Kha TruongBrain Imaging and Analysis Center, Duke University Medical Center, Durham, NC 27710, USA.
David J MaddenBrain Imaging and Analysis Center, Duke University Medical Center, Durham, NC 27710, USA.
Mayan J BedggoodDepartment of Psychology and Neuroscience, Auckland University of Technology, Auckland 0627, New Zealand.ORCID https://orcid.org/0000-0001-5895-4729
Catherine MorganCenter for Advanced MRI, The University of Auckland, Auckland 1023, New Zealand.
Helen C MurrayCenter for Brain Research, The University of Auckland, Auckland 1023, New Zealand.ORCID https://orcid.org/0000-0001-8707-7657
Samantha J HoldsworthCenter for Brain Research, The University of Auckland, Auckland 1023, New Zealand.
Ashley W StewartCenter for Advanced Imaging, The University of Queensland, Queensland 4067, Australia.
Richard L M FaullCenter for Brain Research, The University of Auckland, Auckland 1023, New Zealand.
Patria HumeSchool of Sport and Recreation, Faculty of Health and Environmental Science, Sports Performance Research Institute New Zealand, Auckland University of Technology, Auckland 0627, New Zealand.
Alice TheadomDepartment of Psychology and Neuroscience, Auckland University of Technology, Auckland 0627, New Zealand.ORCID https://orcid.org/0000-0003-0351-6216
Mangor PedersenDepartment of Psychology and Neuroscience, Auckland University of Technology, Auckland 0627, New Zealand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Quantitative susceptibility mapping has been applied to map brain iron distribution after mild traumatic brain injury to understand properties of neural tissue which may be related to cellular dyshomeostasis. However, this is a heterogeneous injury associated with microstructural brain changes, and 'traditional' group-wise statistical approaches may lead to a loss of clinically relevant information, as subtle alterations at the individual level can be obscured by averages and confounded by within-group variability. More precise and individualized approaches are needed to characterize mild traumatic brain injury better and elucidate potential cellular mechanisms to improve intervention and rehabilitation. To address this issue, we use quantitative MRI to build individualized profiles of regional positive (iron-related) magnetic susceptibility across 34 bilateral cortical ROIs following mild traumatic brain injury. Healthy population templates were constructed for each cortical area using standardized

Indexed as

brain ironcerebral cortexindividualized profilesmild traumatic brain injuryquantitative susceptibility mapping

Identifiers

PMID40161218
PMCPMC11954555

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.