ArticleJournal of pain research2025
Impact of Socioeconomic Status on the Risk of Intervertebral Disc Degeneration and Low Back Pain in the European Population and the Mediating Role of Obesity-Related Traits: Evidence from a Mendelian Randomization Study.
Article in Journal of pain research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Causal links between multi-domain risk factors and intervertebral disc degeneration: a systematic review and meta-analysis of Mendelian randomization studies.BMC musculoskeletal disorders · 2026Pooled it
- Activation of the NR3C1-STAT3-SLC6A2 signaling axis by a cyanidin-3-O-glucoside-enriched anthocyanin preparation attenuates neuroinflammation and pain hypersensitivity in intervertebral disc degeneration.Journal of neuroinflammation · 2026Article
- Dietary inadequacies and their association with pain severity and disc degeneration in patients surgically treated for degenerative lumbosacral spine disorders.Frontiers in nutrition · 2026Article
- USP39 inhibits MLKL phosphorylation and deubiquitination to suppress necroptosis of nucleus pulposus cells and attenuate intervertebral disc degeneration.Journal of orthopaedic translation · 2026Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: To identify the causal effect of socioeconomic status (SES) on intervertebral disc degeneration (IVDD) and low back pain risk through Mendelian Randomization (MR) analysis, and to evaluate the mediating role of obesity-related traits in these causal associations. Methods: Genome-wide association summary statistics for SESs ([i] years of schooling, [ii] occupational attainment, [iii] Townsend deprivation index, [iv] job involves heavy manual or physical work, and [v] average total household income before tax), obesity-related traits ([i] body mass index [BMI], [ii] waist circumference, and [iii] hip circumference), IVDD, and low back pain, were obtained from public databases. Inverse variance weighted (IVW) was the primary causal inference approach. Through two-step mediation MR analysis, key obesity-related traits mediating the causal effect of SES on the risk of IVDD and low back pain were identified. Results: This MR study supported that years of schooling reduced the risk of IVDD and low back pain, while the Townsend deprivation index and jobs involving heavy manual or physical work increased the risk of IVDD and low back pain. Additionally, occupational attainment and average total household income before tax reduced the risk of low back pain. Mediation MR analysis indicated that BMI and waist circumference mediated the causal effect of years of schooling, and BMI mediated the causal impact of average total household income before tax. Conclusions: This MR study provided evidence for the causal effect of genetically determined SES on the risk of IVDD and low back pain and revealed the potential mediating effect of obesity-related traits.
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