ArticleJournal of pain research2025
Associations Between Circulating Inflammatory Cytokines and Neuropathic Pain: A Two-Sample Mendelian Randomization Study.
Article in Journal of pain research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Development of a machine learning-based nomogram for predicting chronic postsurgical pain after uniportal video-assisted thoracoscopic surgery.Journal of thoracic disease · 2025Article
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Authors and funding
6 authors.
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Abstract
Purpose: Several recent observational studies have reported that the circulating inflammatory cytokine composition is associated with neuropathic pain. However, the causal effect of 41 circulating inflammatory cytokines on neuropathic pain is unknown. Patients and Methods: A two-sample Mendelian randomization study was performed using summary statistics for a genome-wide association study (GWAS) of circulating inflammatory cytokines conducted within three Finnish cohorts (YFS and FINRISK 1997 and 2002, n=8,293). The summary statistics of neuropathic pain were obtained from the GWAS dataset (800 patients and 195,047 controls). Inverse variance weighting, weighted median weighting, MR‒Egger regression, simple weighting, and weighted weighting were used to examine the causal associations between inflammatory cytokines and neuropathic pain. Sensitivity analyses, including the Cochran Q test, Egger intercept test, and leave-one-out analysis, were performed to verify the robustness of the MR results. Results: Inverse variance weighted estimates suggested that Conclusion: This two-sample Mendelian randomization study revealed that
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