Evidence map›Paper›PMID 40161205›Full record

ArticleJournal of pain research2025

Genetically Supported Causality Between Immune Cells Traits and Low Back Pain: A Bi-Directional Two-Sample Mendelian Randomization Study.

Jianbing Wang, Mengye Zhu, Yuhan Liu, Daying Zhang, Shuchun Yu, Jinjin Zhang

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In one paragraph

Article in Journal of pain research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

6 authors.

Jianbing Wang *Department of Pain Medicine, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, People's Republic of China.
Mengye Zhu *Department of Pain Medicine, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, People's Republic of China.
Yuhan LiuCollege of Medicine, Jinggangshan University, Ji'an, People's Republic of China.
Daying ZhangDepartment of Pain Medicine, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, People's Republic of China.
Shuchun YuDepartment of Anesthesiology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, People's Republic of China.
Jinjin ZhangDepartment of Pain Medicine, Ji'an Central People's Hospital, Ji'an, People's Republic of China.ORCID 0000-0002-7099-9628

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Prior studies have suggested that immune cells play a crucial role in Low Back Pain (LBP). We employed a bi-directional Mendelian randomization (MR) study to investigate the causal relationship of immune cells with the risk of LBP. Patients and Methods: Single Nucleotide Polymorphisms (SNPs) that had a significant genetic association with immune cells were used as instrumental variables (IVs). The inverse variance weighted (IVW) method was used as the primary approach for MR analyses. To assess the robustness, sensitivity analyses were further performed using MR-Egger and MR-PRESSO. Results: The MR analysis revealed a causal relationship between six types of immune cells and LBP ( Conclusion: This study has demonstrated a close genetic connection between immune cells and LBP, providing valuable insights for future clinical research.

Indexed as

immune cellslow back painMendelian randomization

Identifiers

PMID40161205
PMCPMC11952146

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