ArticleCureus2025
Unraveling Visual Field Asymmetry: Insights Into Left-Right Differences in Glaucoma Patients.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
purposePrimary open-angle glaucoma (POAG) typically exhibits bilateral symmetry in visual field defects, while secondary glaucoma often manifests substantial left-right differences. This study investigates the diagnostic relevance of left-right differences in the Humphrey visual field (HVF) test and explores the factors influencing these differences. STUDY
designThis is a cross-sectional study.
methodsParameters were assessed in 201 glaucoma patients, including age, sex, glaucoma disease type, central corneal thickness (CCT), corneal endothelial cell density (ECD), axial length, anterior chamber depth, refractive power, intraocular pressure (IOP), glaucoma drug score, and mean deviation (MD), pattern standard deviation (PSD), and visual field index (VFI) for both eyes in HVF. Patients were categorized into type 1 (POAG in both eyes) and type 2 (secondary glaucoma). Multivariable analysis was conducted to explore factors influencing left-right visual field test differences.
resultsNo significant differences were found between type 1 and type 2 in left-right MD, PSD, and VFI (p=0.13, 0.26, 0.09). Type 2 exhibited significant inter-eye differences in ECD, CCT, IOP, and glaucoma drug scores (p=0.02, <0.01, <0.001, 0.01). In the type 1 group, the left and right MD values were statistically significantly correlated (r=0.40, p<0.000001), but 24.6% of patients showed a left-right difference of 10 dB or more. Multivariable regression analysis identified anterior chamber depth as the sole significant factor influencing left-right MD differences in POAG (p=0.03).
conclusionAsymmetry in the visual field cannot distinguish between glaucoma disease types. In POAG, a shorter anterior chamber depth is associated with increased left-right MD differences, emphasizing its significance in understanding the progression of visual field defects.
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