ReviewCureus2025
Assessing the Clinical Efficacy of Dupilumab and Its Impact on the Quality of Life of Adult Atopic Dermatitis Patients: A Systematic Review.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Minimal Disease Activity as A New Therapeutic Target in Atopic Dermatitis: A 5-Year Real-Life Experience With Dupilumab.International journal of dermatology · 2026Article
- Risk factors for surgical site infection requiring reoperation after osteotomy around the knee: a multicenter retrospective study.BMC musculoskeletal disorders · 2026Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dupilumab, a monoclonal antibody, acts as a dual-action inhibitor that effectively suppresses interleukin-4 (IL-4) and interleukin-13 (IL-13) secretion, which plays an important role in type 2 inflammation. Atopic dermatitis (AD), also known as eczema, is a chronic inflammatory skin disorder that affects both adults and infants. The primary objective of this systematic review was to evaluate the clinical efficacy of dupilumab and the quality of life (QOL) of atopic dermatitis adult patients on dupilumab. Although adults experience a lower percentage of AD as compared to children globally, this disease should be addressed to improve the treatment of this condition in adults. The need for the study arises from the fact that there is a dearth of data regarding the efficacy of dupilumab in atopic dermatitis, particularly in the adult population. An extensive search was conducted using PubMed, Turning Research Into Practice (TRIP), and Cochrane Central Register of Controlled Trials (CENTRAL) and included studies published between 2018 and 2025 in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines 2020. The Medical Subject Headings (MeSH) terms and Boolean operators used were "Dupilumab" OR "Dermatitis, Atopic". All randomized controlled trials (RCTs) were included in this systematic review. Nine full-text articles were ultimately considered, and critical appraisal was performed thereon. Dupilumab at a dose of 300 mg once every two weeks (q2w) and 300 mg once weekly (qw) were effective in treating atopic dermatitis by improving symptoms of pruritus, pain, and depression and preventing the spread of the disease. The quality of life (QOL) improved significantly, and the rate of atopic dermatitis hospitalization decreased after the use of dupilumab.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.