Evidence map›Paper›PMID 40161146›Full record

ArticleCureus2025

Acute Liver Injury Following Herbal Drink Consumption With Steatosis and Immune Activation: A Case Report.

Helai Hussaini, Aiman Waheed, Olaniyi Fadeyi, Tony Boostany, Yusuke Hashimoto, Andrew T Flint

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Helai HussainiInternal Medicine, West Anaheim Medical Center (WAMC), Orange, USA.
Aiman WaheedMedicine, Holy Family Hospital, Rawalpindi, PAK.
Olaniyi FadeyiGastroenterology, West Anaheim Medical Center (WAMC), Orange, USA.
Tony BoostanyGastroenterology, University of Florida College of Medicine - Jacksonville, Jacksonville, USA.
Yusuke HashimotoGastroenterology, University of Florida College of Medicine - Jacksonville, Jacksonville, USA.
Andrew T FlintGeneral Medicine, University of Florida College of Medicine - Jacksonville, Jacksonville, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herbal medicines are widely used for their perceived health benefits; however, their potential for liver toxicity is well-documented. We report a case of acute liver injury (ALI) in a 32-year-old male patient following the consumption of a multi-herbal drink. The patient, with a history of cholecystectomy for gallstones and nephrolithiasis, presented with severe epigastric pain radiating to the right shoulder, nausea, high blood pressure (170/113 mmHg), and a rapid heart rate. Laboratory tests revealed significant liver damage, with aspartate aminotransferase (AST) at 1,043 U/L, alanine aminotransferase (ALT) at 1,645 U/L, and total bilirubin at 4.8 mg/dL. Ultrasound imaging showed fatty liver disease without bile duct obstruction. Autoimmune testing was negative for antinuclear antibodies (ANA) and antimitochondrial antibodies (AMA), while elevated immunoglobulin G (IgG) levels suggested immune activation as a potential mechanism. The patient improved with supportive care. This case highlights the potential liver toxicity of polyherbal remedies and underscores the importance of early recognition and management to prevent long-term complications.

Indexed as

acute liver injuryhepatic steatosishepatotoxicityherbal-induced liver injuryimmune activation

Identifiers

PMID40161146
PMCPMC11955213

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.