ArticleCureus2025
An Observational Study of Glycopegylated Extended Half-Life Factor Prophylaxis in Hemophilia A and B in a Tertiary Care Center in India.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Evolving landscape of haemophilia care in India: Balancing innovation, access, and sustainability.The Indian journal of medical research · 2026Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prophylactic treatment for hemophilia in India remains significantly underutilized compared to developed nations, leading to reliance on episodic therapy with limited long-term benefits. This study evaluated the efficacy and safety of glycopegylated extended half-life (EHL) clotting factors in patients with hemophilia A and B. A retrospective observational design was employed, including 25 patients aged ≥18 years with moderate or severe hemophilia A or B who transitioned to EHL therapy. Hemophilia A patients (n=19) switched from standard half-life (SHL) factor VIII (FVIII) to weekly EHL FVIII prophylaxis, while hemophilia B patients (n=6) transitioned from on-demand SHL factor IX (FIX) to glycopegylated EHL FIX prophylaxis every 21 days. Outcomes were assessed through the annual bleeding rate (ABR), functional independence score in hemophilia (FISH score), and hemophilia joint health score (HJHS). A subset analysis for quality of life (QoL) was also performed on hemophilia A patients using the Haem-A-QoL questionnaire in patients with hemophilia A. Glycopegylated EHL FVIII therapy significantly reduced ABR and improved joint health and functional scores over 24 months (p<0.001). Hemophilia B patients demonstrated a significant reduction in ABR and joint bleeding rates at eight months (p<0.05). The study found that prophylaxis with individualized doses of glycopegylated EHL factors is not only effective in reducing bleeding episodes and improving joint health but also safe with improved treatment adherence, offering a viable prophylactic option in resource-constrained settings.
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