ArticleCureus2025
Kaposi Sarcoma Masquerading as Methicillin-Resistant Staphylococcus aureus Soft Tissue Infection of the Foot in an Immunocompromised Transgender Female.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Kaposi sarcoma (KS) is an acquired immunodeficiency syndrome-defining malignancy caused by human herpesvirus-8 (HHV-8), predominantly affecting immunocompromised individuals, particularly those with untreated or advanced human immunodeficiency virus (HIV). Here, we present the case of a 28-year-old homeless transgender female with untreated HIV (CD4 count = 175 cells/μL, HIV RNA = 221,000 copies/mL), latent syphilis, and methamphetamine use disorder, who presented with a five-month history of progressive left foot pain, ulceration, and swelling. Initial examination revealed extensive bilateral lower extremity ulcerative lesions, with a necrotic, violaceous mass on the left hallux and a similar lesion on the right medial ankle, raising suspicion for KS. However, the presence of purulent drainage and surrounding erythema suggested a superimposed bacterial infection. Bedside incision and drainage of the left hallux lesion was performed, followed by formal surgical debridement and excision of infected soft tissue masses. Histopathologic examination confirmed KS, characterized by spindle cell proliferation, slit-like vascular channels, and HHV-8 positivity on immunohistochemical staining. Wound cultures grew methicillin-resistant
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