ArticleClinical case reports2025
Application of 35 kDa Hyaluronic Acid Fragment in Managing Persistent Localized Pain in Rheumatoid Arthritis : A Case Report.
Article in Clinical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Analysis of Implant Osseointegration, Bone Repair, and Sinus Mucosa Integrity Using Bio-OssDentistry journal · 2025Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by systemic joint inflammation, leading to joint damage and pain. This case report presents a 58-year-old Chinese female who developed widespread joint pain after contracting mild COVID-19 and was subsequently diagnosed with RA. Her symptoms included joint swelling, pain, and abnormal serological markers. Initial treatment with methylprednisolone and tofacitinib was discontinued due to side effects, and she switched to a combined approach of herbal and Western medicine. After a year of treatment, her widespread pain and joint swelling largely resolved, leaving persistent localized pain in specific joints. To address this persistent localized pain, she received 35 kDa hyaluronan fragment (HA35) injections, resulting in significant improvement, including complete relief of elbow and knee pain and restored joint mobility. Continuous HA35 injections, followed by oral HA35 powder, also completely relieved her foot pain. This case highlights the effectiveness of HA35 in managing persistent RA pain, particularly for residual pain after conventional treatments, and suggests its potential as a therapeutic option.
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