Evidence map›Paper›PMID 40160921›Full record

ArticleIndian journal of anaesthesia2025

Effects of perioperative oxycodone as the sole opioid on immunity within a multi-modal analgesia framework in patients undergoing cervical cancer surgery: A randomised controlled trial.

Jingjing Liu, Sumeng Chen, Jianxiao Chen, Hailian Liu, Weiyi Li, Haomin Chi, Xiaowei Ding, Shaoqiang Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Indian journal of anaesthesia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jingjing LiuDepartment of Anaesthesiology, Obstetrics and Gynaecology Hospital of Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-6356-6613
Sumeng ChenDepartment of Anaesthesiology, Obstetrics and Gynaecology Hospital of Fudan University, Shanghai, China.ORCID https://orcid.org/0009-0002-1069-7801
Jianxiao ChenDepartment of Anaesthesiology, Shangyu Maternal and Child Health Care Hospital, Shaoxing, Zhejiang, China.ORCID https://orcid.org/0000-0001-7064-925X
Hailian LiuDepartment of Anaesthesiology, Obstetrics and Gynaecology Hospital of Fudan University, Shanghai, China.ORCID https://orcid.org/0009-0001-8892-6566
Weiyi LiDepartment of Anaesthesiology, Obstetrics and Gynaecology Hospital of Fudan University, Shanghai, China.ORCID https://orcid.org/0009-0004-5926-1886
Haomin ChiDepartment of Anaesthesiology, Obstetrics and Gynaecology Hospital of Fudan University, Shanghai, China.ORCID https://orcid.org/0009-0006-0650-5474
Xiaowei DingDepartment of Anaesthesiology, Obstetrics and Gynaecology Hospital of Fudan University, Shanghai, China.ORCID https://orcid.org/0009-0007-4072-2322
Shaoqiang HuangDepartment of Anaesthesiology, Obstetrics and Gynaecology Hospital of Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-0515-8099

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aims: Current views on oxycodone's effects on immunity are inconsistent. Our objective was to compare the effects of perioperative oxycodone as the sole opioid in a multi-modal analgesia regimen with conventional opioid regimens on immunity in cervical cancer. Methods: In this randomised controlled trial (RCT), patients scheduled for laparoscopic radical hysterectomy for cervical cancer were randomised to receive either oxycodone (Group O) or conventional opioid regimens (Group C). The primary outcome was the CD4 Results: We included 56 patients in the final analysis. The postoperative CD4 Conclusion: In laparoscopic surgery for cervical cancer, perioperative oxycodone as the sole opioid within a multi-modal analgesia framework does not yield anticipated benefits in immunopreservation compared to conventional opioid regimens but improves postoperative pain management and haemodynamic stability.

Indexed as

Analgesiaanalgesicscancerhaemodynamicsimmunityimmunomodulationimmunoprotectiveimmunosuppressionopioidoxycodoneuterine cervical neoplasms

Identifiers

PMID40160921
PMCPMC11949401

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.