Evidence map›Paper›PMID 40160909›Full record

ArticleIndian journal of anaesthesia2025

Levobupivacaine versus ropivacaine for brachial plexus block: A systematic review and meta-analysis of randomised controlled trials.

Abdullah M Alharran, Muteb N Alotaibi, Yaqoub Y Alenezi, Yousef M Alharran, Ahmad A Alahmad, Abdulmuhsen Alqallaf, Mohammad F Al-Mutairi, Abdulbadih R Saad, Mohammed H Alazemi, Duaij S Saif and 2 more

Abstract read
In one paragraph

Article in Indian journal of anaesthesia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Automated tools in systematic reviews: Current trends.Indian journal of anaesthesia · 2025
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Abdullah M AlharranDepartment of Medicine and Surgery, Arabian Gulf University, Manama, Kingdom of Bahrain.ORCID https://orcid.org/0009-0003-2337-6588
Muteb N AlotaibiDepartment of Medicine and Surgery, Alfaisal University, Riyadh, Kingdom of Saudi Arabia.ORCID https://orcid.org/0009-0002-2808-4501
Yaqoub Y AleneziDepartment of Medicine and Surgery, Arabian Gulf University, Manama, Kingdom of Bahrain.ORCID https://orcid.org/0009-0009-0836-1947
Yousef M AlharranDepartment of Medicine and Surgery, Alexandria Faculty of Medicine, Alexandria, Egypt.ORCID https://orcid.org/0009-0003-0227-0397
Ahmad A AlahmadDepartment of Medicine and Surgery, Royal College of Surgeons in Ireland, Dublin, Ireland.ORCID https://orcid.org/0009-0009-1503-5592
Abdulmuhsen AlqallafDepartment of Medicine and Surgery, Kuwait Institute for Medical Specializations (KIMS), Kuwait City, Kuwait.ORCID https://orcid.org/0009-0002-7261-1380
Mohammad F Al-MutairiDepartment of Medicine and Surgery, Arabian Gulf University, Manama, Kingdom of Bahrain.ORCID https://orcid.org/0009-0006-2901-7887
Abdulbadih R SaadDepartment of Medicine and Surgery, Arabian Gulf University, Manama, Kingdom of Bahrain.ORCID https://orcid.org/0009-0006-1452-0287
Mohammed H AlazemiDepartment of Medicine and Surgery, Alexandria Faculty of Medicine, Alexandria, Egypt.ORCID https://orcid.org/0009-0003-8890-8952
Duaij S SaifDepartment of Medicine and Surgery, Arabian Gulf University, Manama, Kingdom of Bahrain.ORCID https://orcid.org/0009-0009-5872-0901
Ebraheem AlbazeeDepartment of Otorhinolaryngology-Head and Neck Surgery, Kuwait Institute for Medical Specializations (KIMS), Kuwait City, Kuwait.ORCID https://orcid.org/0000-0003-1244-7769
Ahmad Y AlmohammadDepartment of Orthopedics, Ministry of Health, Kuwait City, Kuwait.ORCID https://orcid.org/0009-0008-0364-9362

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aims: Brachial plexus block (BPB) is advantageous for elective orthopaedic or reconstructive upper limb surgery. However, the optimal local anaesthetic in BPB remains debatable. Therefore, we aim to investigate the efficacy and safety of levobupivacaine versus ropivacaine in BPB for upper limb surgery. Methods: A systematic review and meta-analysis synthesising randomised controlled trials (RCTs), retrieved by systematically searching PubMed, EMBASE, WOS, SCOPUS, Google Scholar, and CENTRAL since inception till June 2024. Continuous and dichotomous outcome variables were pooled using mean difference (MD) and risk ratio (RR), with a 95% confidence interval (CI), using Stata v. 17. We assessed heterogeneity using the Chi-square test and I Results: Sixteen RCTs and 939 patients were included. Levobupivacaine was significantly associated with a longer sensory block duration [MD: 1.66 (95% CI: 1.43, 1.89), Conclusions: Levobupivacaine is significantly associated with a longer duration of sensory and motor block in patients undergoing BPB for upper limb surgery compared to ropivacaine, with a similar safety profile. However, there was no difference regarding the time to onset of the sensory or motor block.

Indexed as

Analgesiabrachial plexus blocklevobupivacainemeta-analysisropivacainesurgerysystematic reviewupper limb

Identifiers

PMID40160909
PMCPMC11949393

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.