Evidence map›Paper›PMID 40160878›Full record

ArticleInternational cancer conference journal2025

Gastrectomy after neoadjuvant chemotherapy in five cases of locally advanced gastric cancer with pancreatic head invasion.

Mikihiro Kano, Noriaki Tokumoto, Kazuaki Tanabe, Jun Hihara, Kazuhiro Toyota, Ryuichi Hotta, Yoshihiro Saeki, Hirofumi Tazawa, Nobuaki Fujikuni, Hiroshima Surgical Study Group of Clinical Oncology (HiSCO)

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Article in International cancer conference journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

10 authors.

Mikihiro KanoDepartment of Digestive Surgery, Hiroshima City North Medical Center Asa Citizens Hospital, 1-2-1 Kameyama-minami, Asakita-ku, Hiroshima, 7310293 Japan.
Noriaki TokumotoDepartment of Digestive Surgery, Hiroshima City North Medical Center Asa Citizens Hospital, 1-2-1 Kameyama-minami, Asakita-ku, Hiroshima, 7310293 Japan.
Kazuaki TanabeDepartment of Perioperative and Critical Care Management, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Jun HiharaDepartment of Digestive Surgery, Hiroshima City North Medical Center Asa Citizens Hospital, 1-2-1 Kameyama-minami, Asakita-ku, Hiroshima, 7310293 Japan.
Kazuhiro ToyotaDepartment of Surgery, Hiroshima Memorial Hospital, Hiroshima, Japan.
Ryuichi HottaDepartment of Surgery, National Hospital Organization Higashihiroshima Medical Center, Higashihiroshima, Japan.
Yoshihiro SaekiDepartment of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan.
Hirofumi TazawaDepartment of Surgery, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure, Japan.
Nobuaki FujikuniDepartment of Digestive Surgery, Hiroshima Prefectural Hospital, Hiroshima, Japan.
Hiroshima Surgical Study Group of Clinical Oncology (HiSCO)

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Locally advanced gastric cancer (LAGC) with pancreatic head invasion (T4b) carries a poor prognosis despite radical surgery. Herein, we report the effectiveness of neoadjuvant chemotherapy (NAC) in improving the resectability of advanced gastric cancer with pancreatic invasion. A total of 2191 cases of gastric cancer were retrospectively analyzed from 13 institutions within the Hiroshima Surgical Study Group of Clinical Oncology (Hisco) database from 2018 to 2020. Among them, 5 of the 24 patients with Stage cT4b gastric cancer underwent NAC for three-to-eight cycles. Following chemotherapy, three patients underwent total gastrectomy, two patients underwent distal gastrectomy, and no patient underwent pancreaticoduodenectomy (PD). All five patients achieved a chemotherapeutic response of Grade 1b or higher, and only one case showed residual pancreatic invasion on pathology. This study suggests that NAC for Stage T4b LAGC with pancreatic head invasion may have the potential to obviate the need for PD.

Indexed as

Gastric cancerNeoadjuvant chemotherapyPancreatic invasion

Identifiers

PMID40160878
PMCPMC11950593

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.