Evidence map›Paper›PMID 40160876›Full record

ArticleInternational cancer conference journal2025

Anastrozole-induced interstitial lung disease followed by tamoxifen-induced agranulocytosis in a patient with breast cancer.

Maki Juge, Takako Imada, Mizuki Hirose, Ken Sato

Abstract read
In one paragraph

Article in International cancer conference journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Maki JugeDepartment of Breast Surgery, Okayama Central Hospital, 6-3 Ishimakita-Machi, Okayama, 700-0017 Japan.ORCID 0009-0003-5686-027X
Takako ImadaDepartment of Breast Surgery, Okayama Central Hospital, 6-3 Ishimakita-Machi, Okayama, 700-0017 Japan.
Mizuki HiroseDepartment of Radiotherapy, Okayama Central Hospital, 6-3 Ishimakita-Machi, Okayama, 700-0017 Japan.
Ken SatoDepartment of Respiratory Medicine, National Hospital Organization Okayama Medical Center, 1711-1 Tamasu, Okayama, 701-1192 Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 70-year-old woman with the breast cancer exhibited interstitial lung disease 20 months after the administration with anastrozole, which was performed as the post-operative adjuvant therapy. The drug-induced lymphocyte stimulation test revealed that anastrozole was responsible for the development of interstitial lung disease in this patient. The interstitial lung disease was effectively treated by prednisolone. Then, tamoxifen was used as an alternative therapy, resulting in the occurrence of agranulocytosis 24 days after the administration with tamoxifen. Both anastrozole and tamoxifen are widely used and are highly effective drugs for the treatment of breast cancer. However, the current patient shows that both drugs could cause, albeit very rare, serious side effects in some patients.

Indexed as

AgranulocytosisAnastrozoleBreast cancerInterstitial lung diseaseTamoxifen

Identifiers

PMID40160876
PMCPMC11950607

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.