Evidence map›Paper›PMID 40160815›Full record

ArticleFrontiers in immunology2025

A pooled CRISPR screen identifies the Tα2 enhancer element as a driver of

Pascal Y Schönberg, Ángela Muñoz-Ovalle, Maciej Paszkowski-Rogacz, Eugenia Crespo, Duran Sürün, Anja Feldmann, Frank Buchholz

Abstract read
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In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Pascal Y SchönbergMedical Systems Biology, Faculty of Medicine Carl Gustav Carus, Technical University Dresden, Dresden, Germany.
Ángela Muñoz-OvalleMedical Systems Biology, Faculty of Medicine Carl Gustav Carus, Technical University Dresden, Dresden, Germany.
Maciej Paszkowski-RogaczMedical Systems Biology, Faculty of Medicine Carl Gustav Carus, Technical University Dresden, Dresden, Germany.
Eugenia CrespoInstitute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden Rossendorf (HZDR), Dresden, Germany.
Duran SürünMedical Systems Biology, Faculty of Medicine Carl Gustav Carus, Technical University Dresden, Dresden, Germany.
Anja FeldmannInstitute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden Rossendorf (HZDR), Dresden, Germany.
Frank BuchholzMedical Systems Biology, Faculty of Medicine Carl Gustav Carus, Technical University Dresden, Dresden, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The T cell receptor (TCR) is crucial for immune responses and represents a pivotal therapeutic target for CAR T cell therapies. However, which enhancer elements drive the constitutive expression of the TCRα chain in mature, peripheral T cells has not been well defined. Earlier work has suggested that enhancer alpha is inactive in mature peripheral T cells and that an alternative enhancer element in the 5' J region was driving

Indexed as

Clustered Regularly Interspaced Short Palindromic RepeatsCRISPR-Cas SystemsEnhancer Elements, GeneticGene Expression RegulationReceptors, Antigen, T-Cell, alpha-betaT-LymphocytesT-Lymphocyte SubsetsHumansJurkat CellsReceptors, Antigen, T-Cell, alpha-betaCAR T cellsCRISPR screenenhancer alphagenome editingTCR expressionTRA locusTRA regulation

Identifiers

PMID40160815
PMCPMC11949936

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.