ArticleACS omega2025
Ligand-Accelerated, Copper-Catalyzed Aerobic Oxidative Dehydrogenation of Primary Amines to Nitriles.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Homogeneous copper-catalyzed aerobic oxidation of alcohols and aldehydes: mechanistic insights and recent advances.Beilstein journal of organic chemistry · 2026Review
- Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A highly efficient copper-catalyzed oxidative dehydrogenation of primary amines to access nitriles has been developed. We found that DMAP was an efficient ligand for copper-catalyzed oxidation and molecular oxygen was a green oxidizing agent. This reaction exhibited excellent functional group compatibility and a broad substrate scope. Various benzylic, allylic, and aliphatic amines were selectively and effectively oxidized to the corresponding nitriles in high yields (up to 100%). The ligand DMAP not only accelerated the reaction rate but also enhanced the stability of the catalyst. The practicality of the reaction was illustrated on a gram scale, even at a lower catalyst loading and/or under bubble air conditions.
Identifiers
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Registered trials
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