Transcriptome Analysis of Trigeminal Ganglion and Medullary Dorsal Horn in Mice to Identify Potential Targets for Pulpitis-Induced Pain.

Zhuo Yu, Xiaoning Kang, Jialin Si, Ruijing Ping, Xia Yan, Xiaoke Wu, Jing Huang, Li-An Wu

Abstract read

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Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

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8 authors.

Zhuo YuState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Pediatric Dentistry, School of Stomatology, The Fourth Military Medical University, Xi'an 710032, China.ORCID https://orcid.org/0009-0007-8532-3747

Xiaoning KangState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Pediatric Dentistry, School of Stomatology, The Fourth Military Medical University, Xi'an 710032, China.

Jialin SiState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Pediatric Dentistry, School of Stomatology, The Fourth Military Medical University, Xi'an 710032, China.

Ruijing PingState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Pediatric Dentistry, School of Stomatology, The Fourth Military Medical University, Xi'an 710032, China.

Xia YanState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Pediatric Dentistry, School of Stomatology, The Fourth Military Medical University, Xi'an 710032, China.

Xiaoke WuState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Pediatric Dentistry, School of Stomatology, The Fourth Military Medical University, Xi'an 710032, China.

Jing HuangDepartment of Neurobiology, School of Basic Medical Sciences, The Fourth Military Medical University, Xi'an 710032, China.

Li-An WuState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Pediatric Dentistry, School of Stomatology, The Fourth Military Medical University, Xi'an 710032, China.ORCID https://orcid.org/0000-0001-8909-328X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pulpitis is a common oral disease associated with severe pain, which is often accompanied by sleep disturbances and anxiety-like symptoms. There is currently no specific analgesic medication available to alleviate pulpitis-induced pain. In the current study, we applied transcriptomics to conduct a bioinformatics screening of the trigeminal ganglion (TG) and the medullary dorsal horn (MDH) over a 7-day period of pulp exposure, aiming to identify key differentially expressed genes (DEGs). We identified three key DEGs in the TG and three in the MDH, which are primarily involved in pathways related to immune responses, inflammatory responses, and neuroactive ligand-receptor interactions. Potential drug candidates were pinpointed through virtual screening of key DEGs, followed by molecular docking and molecular dynamics analysis. Notably,

Identifiers

PMID40160770

DOI10.1021/acsomega.4c11486

PMCPMC11947827

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.