Evidence map›Paper›PMID 40160691›Full record

ArticleWorld journal of stem cells2025

Mesenchymal stem cell exosomes enhance the development of hair follicle to ameliorate androgenetic alopecia.

Yu Fu, Yao-Ting Han, Jun-Ling Xie, Rong-Qi Liu, Bo Zhao, Xing-Liao Zhang, Jun Zhang, Jing Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of stem cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yu FuResearch Center for Translational Medicine at East Hospital, School of Life Science and Technology, Tongji University, Shanghai 200092, China.
Yao-Ting HanResearch Center for Translational Medicine at East Hospital, School of Life Science and Technology, Tongji University, Shanghai 200092, China.
Jun-Ling XieResearch Center for Translational Medicine at East Hospital, School of Medicine, Tongji University, Shanghai 200092, China.
Rong-Qi LiuResearch Center for Translational Medicine at East Hospital, School of Life Science and Technology, Tongji University, Shanghai 200092, China.
Bo ZhaoResearch Center for Translational Medicine at East Hospital, School of Life Science and Technology, Tongji University, Shanghai 200092, China.
Xing-Liao ZhangResearch Center for Translational Medicine at East Hospital, School of Medicine, Tongji University, Shanghai 200092, China.
Jun ZhangTongji Lifeng Institute of Regenerative Medicine, Tongji University, Shanghai 200092, China.
Jing ZhangTongji Lifeng Institute of Regenerative Medicine, Tongji University, Shanghai 200092, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMesenchymal stem cells (MSCs) and their secretome have significant potential in promoting hair follicle development. However, the effects of MSC therapy have been reported to vary due to their heterogeneous characteristics. Different sources of MSCs or culture systems may cause heterogeneity of exosomes.

aimTo define the potential of human adipose-derived MSC exosomes (hADSC-Exos) and human umbilical cord-derived MSC exosomes (hUCMSC-Exos) for improving dermal papillary cell proliferation in androgenetic alopecia.

methodsWe conducted liquid chromatography-mass spectrometry proteomic analysis of hADSC-Exos and hUCMSC-Exos. Liquid chromatography-mass spectrometry suggested that hADSC-Exos were related to metabolism and immunity. Additionally, the hADSC-Exo proteins regulated the cell cycle and other 9 functional groups.

resultsWe verified that hADSC-Exos inhibited glycogen synthase kinase-3β expression by activating the Wnt/β-catenin signaling pathway

conclusionThis study indicated that hair development is influenced by hADSC-Exo-mediated cell-to-cell communication

Indexed as

Dermal papillary cellsExosomeHair developmentLiquid chromatography-mass spectrometry proteomic analysisMesenchymal stem cells

Identifiers

PMID40160691
PMCPMC11947894

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.