ArticleNational science review2025
Out-of-Africa migration and clonal expansion of a recombinant Epstein-Barr virus drives frequent nasopharyngeal carcinoma in southern China.
Article in National science review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Targeted Epstein-Barr virus capture sequencing identifies BBLF4-L322M as an independent prognostic variant in nasopharyngeal carcinoma.Microbiology spectrum · 2026Article
- Co-Culture of nasopharyngeal carcinoma cells and fibroblasts induces altered integrin expression associated with 3D structural formation.Cytotechnology · 2026Article
- Article
- EBV Genome Variations and Association With Diseases.Journal of medical virology · 2026Review
- Exploring EBNA3C Genetic Variability and Recombination in Epstein-Barr Virus-Associated Cancers.International journal of molecular sciences · 2026Article
- Over one-third of cancer cases and two-fifths of cancer deaths in southern China are preventable: Insights from the latest representative population-based cancer registry data and risk factor survey.International journal of cancer · 2026Article
- The triad of nasopharyngeal carcinoma pathogenesis: host genetics, viral infection, and environmental exposures.Frontiers in oncology · 2026Review
- Targeted demethylation of the BRD7 promoter based on CRISPR/dCas9 system inhibits the malignant progression of nasopharyngeal carcinoma.Clinical and translational medicine · 2026Article
- A specific tsRNA in serum from patients with nasopharyngeal carcinoma: 5'tiRNA-32-ValAAC-2 mediates malignance of nasopharyngeal carcinoma cells.Frontiers of medicine · 2025Article
- A tale of two species: the origin of the Cantonese cancer in southern China.National science review · 2025Article
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Abstract
While Epstein-Barr virus (EBV) infection is ubiquitous globally, a high-risk EBV subtype associated with the extremely high incidence of nasopharyngeal carcinoma (NPC) was found in southern China, but the evolution history of EBV in humans and the origin of this high-risk subtype remains enigmatic. By obtaining one of the largest datasets of EBV genomes across the world, we found that EBV had an evolutionary history matching the out-of-Africa migration of humans. Within the high-risk subtype from southern China, we identified a rapidly expanding clonal strain originating from a recombination event between EBV strains from northern and southern Chinese around 4000 years ago, followed by strong Darwinian evolution with a fitness advantage of 4%. The clonal strain has almost doubled the risk for NPC compared to the high-risk subtype and explained around 66% of the NPCs, representing the highest risk factor for NPC identified so far. Taken together, we unraveled a strong co-evolution history between EBV and humans where human migration and admixture triggered subsequent recombination and expansion of a highly advantageous EBV strain, leading to a cancer epidemic in southern China.
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