Evidence map›Paper›PMID 40160677›Full record

ArticleNational science review2025

Towards next-generation DNA encryption via an expanded genetic system.

Xiaoluo Huang, Zhaohua Hou, Wei Qiang, Honglei Wang, Xiangxiang Wang, Xiaoxu Chen, Xin Hu, Junbiao Dai, Lingjun Li, Guanghou Zhao

Abstract read
In one paragraph

Article in National science review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Highly Secure In Vivo DNA Data Storage Driven by Genomic Dynamics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiaoluo HuangShenzhen Key Laboratory of Synthetic Genomics, Guangdong Provincial Key Laboratory of Synthetic Genomics, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Zhaohua HouSchool of Ecology and Environment, Northwestern Polytechnical University, Xi'an 710129, China.
Wei QiangShenzhen Key Laboratory of Synthetic Genomics, Guangdong Provincial Key Laboratory of Synthetic Genomics, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Honglei WangHenan Key Laboratory of Organic Functional Molecule and Drug Innovation, Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, School of Chemistry and Chemical Engineering, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang 453007, China.
Xiangxiang WangSchool of Ecology and Environment, Northwestern Polytechnical University, Xi'an 710129, China.
Xiaoxu ChenSchool of Ecology and Environment, Northwestern Polytechnical University, Xi'an 710129, China.
Xin HuSchool of Ecology and Environment, Northwestern Polytechnical University, Xi'an 710129, China.
Junbiao DaiShenzhen Key Laboratory of Synthetic Genomics, Guangdong Provincial Key Laboratory of Synthetic Genomics, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.ORCID https://orcid.org/0000-0002-5299-4700
Lingjun LiHenan Key Laboratory of Organic Functional Molecule and Drug Innovation, Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, School of Chemistry and Chemical Engineering, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang 453007, China.
Guanghou ZhaoSchool of Ecology and Environment, Northwestern Polytechnical University, Xi'an 710129, China.ORCID https://orcid.org/0000-0002-3818-4090

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Information encryption based on DNA data archiving, referred to as DNA encryption, has been advocated for decades and has become highly appealing owing to its remarkable advantages, e.g. high storage capacity, complexity and programmability. Early DNA encryption schemes primarily leveraged the natural four-letter genetic alphabet for data storage, with message-storing DNA sequences easily decrypted by routine DNA sequencing, which is consequently vulnerable to attack and faces severe security challenges. Here, an unnatural base pair (UBP), dNaM-dTPT3, was introduced into the message and/or index DNA sequences, which can be stored either

Indexed as

Codec algorithmDNA data storagemultilevel DNA encryptionunnatural base pair

Identifiers

PMID40160677
PMCPMC11951100

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.