ArticleQuantitative imaging in medicine and surgery2025
Fat-separated T1 mapping for liver function analysis on gadoxetic acid-enhanced MR imaging: 2D two-point Dixon Look-Locker inversion recovery sequence for differentiation of Child-Pugh class B/C from Child-Pugh class A/chronic liver disease.
Article in Quantitative imaging in medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Clinical feasibility of accelerated whole liver water TEuropean radiology experimental · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: T1 relaxation time is a tissue-specific parameter that correlates with liver fibrosis, and can be a valuable tool for detecting and staging of liver disease. However, T1 can be affected by histological factors such as fat, so it is necessary to study the effects of hepatic steatosis when assessing liver function and fibrosis. The purpose of this study is to investigate the fat separation effect of T1 mapping using Dixon watermap Look-Locker inversion recovery (LLIR) in the assessment of liver function on gadoxetic acid (GA)-enhanced magnetic resonance imaging (MRI). Methods: A total of 226 patients who underwent 3T MRI, including a 2D Dixon fat-separated LLIR T1 mapping, were included retrospectively. Two independent readers measured pre- and post-contrast T1 relaxation times (preT1 and postT1) on composite and watermap T1, and reproducibility was evaluated. The correlation of T1 parameters with biochemical and imaging biomarkers of liver function were assessed on both composite and Dixon watermap images; T1 parameters included averaged preT1, postT1 values, changes between pre- and post-T1liver (deltaT1) and adjusted T1liver (postT1liver - T1spleen/T1spleen). And the diagnostic performance of T1 parameters for Child-Pugh (CP) class was also evaluated. Results: Inter- and intra-reader reproducibility showed almost perfect agreement [intraclass correlation coefficient (ICC) 0.929-0.999]. Watermap preT1 (r=-0.125, P=0.068) and watermap deltaT1 (r=0.055, P=0.414) showed loss of correlation with fat fraction (FF) compared with preT1 and deltaT1. Albumin, total bilirubin (TB), hepatobiliary enhancement grade, and R2* (1/T2*), were significantly associated with watermap T1, eliminating the effect of FF. Area under the curve (AUC) of preT1, watermap preT1, deltaT1, postT1, watermap adjusted T1, and adjusted T1 were 0.681 [standard error (SE) 0.114], 0.748 (SE 0.098), 0.921 (SE 0.033), 0.951 (SE 0.018), 0.950 (SE 0.018), and 0.973 (SE 0.013) respectively, for differentiating patient with CP class B/C from CP-A/chronic liver disease (CLD). Conclusions: T1 values using Dixon watermap LLIR eliminated the confounding effect of fat and showed the correlation with serological and imaging markers of liver function. Adjusted T1, watermap adjusted T1, and postT1 showed the highest diagnostic performance in differentiating CP class B/C from CP-A/CLD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.