Evidence map›Paper›PMID 40160580›Full record

ArticleReviews in cardiovascular medicine2025

Mitochondrial DNA Polymorphisms of Peripheral Blood Mononuclear Cells Associated with Sustained Ventricular Tachycardia in Patients with Cardioverter-Defibrillator Implantation Indications.

Tariel Atabekov, Viacheslav Korepanov, Sergey Krivolapov, Mikhail Khlynin, Sergey Afanasiev, Maria Golubenko, Roman Batalov, Sergey Popov

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Reviews in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03667989 (Single-photon Emission Computed Tomography for Prediction and Evaluation of Cardiac Resynchronization Therapy Efficacy in Chronic Heart Failure Patients), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03667989 nacompletednot on this map

Single-photon Emission Computed Tomography for Prediction and Evaluation of Cardiac Resynchronization Therapy Efficacy in Chronic Heart Failure Patients

TypeinterventionalSponsorTomsk National Research Medical Center of the Russian Academy of SciencesRan2017 to 2020Enrolled60ConditionsChronic Heart FailureArmsAssessment of cardiac sympathetic innervation by 123I-MIBG
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tariel AtabekovDepartment of Surgical Arrhythmology and Cardiac Pacing, Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 634012 Tomsk, Russia.ORCID https://orcid.org/0000-0003-2645-4142
Viacheslav KorepanovLaboratory of Molecular and Cellular Pathology and Gene Diagnostics, Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 634012 Tomsk, Russia.ORCID https://orcid.org/0000-0002-2818-1419
Sergey KrivolapovDepartment of Surgical Arrhythmology and Cardiac Pacing, Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 634012 Tomsk, Russia.ORCID https://orcid.org/0000-0001-8121-8287
Mikhail KhlyninDepartment of Surgical Arrhythmology and Cardiac Pacing, Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 634012 Tomsk, Russia.ORCID https://orcid.org/0000-0002-9885-5204
Sergey AfanasievLaboratory of Molecular and Cellular Pathology and Gene Diagnostics, Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 634012 Tomsk, Russia.ORCID https://orcid.org/0000-0001-6066-3998
Maria GolubenkoLaboratory for Population Genetics, Research Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Sciences, 634050 Tomsk, Russia.ORCID https://orcid.org/0000-0002-7692-9954
Roman BatalovDepartment of Surgical Arrhythmology and Cardiac Pacing, Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 634012 Tomsk, Russia.ORCID https://orcid.org/0000-0003-1415-3932
Sergey PopovDepartment of Surgical Arrhythmology and Cardiac Pacing, Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 634012 Tomsk, Russia.ORCID https://orcid.org/0000-0002-9050-4493

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Mitochondrial dysfunction in myocardium cells has been implicated in arrhythmogenesis, including ventricular tachycardia (VT). A carriage of point mitochondrial DNA (mtDNA) polymorphisms may contribute to the risk of certain arrhythmias. Therefore, it is hypothesized that mtDNA genotype could predict the risk of sustained VT ( Methods: A total of 122 patients with ICD implantation indications who underwent transthoracic echocardiography (TTE) were enrolled in the study. Total DNA from PBMC was isolated using the phenol-chloroform extraction method. Genotyping of mtDNA polymorphisms A2706G, G3010A and G9055A was performed using restriction fragment length polymorphism analysis. Correlations between clinical parameters and mtDNA polymorphisms with Results: Prior to ICD implantation, 70 (56.6%) patients had Conclusions: In patients with ICD implantation indications, a carriage of mtDNA polymorphism A2706G is associated with Clinical Trial Registration: NCT03667989 (https://clinicaltrials.gov/study/NCT03667989).

Indexed as

cardioverter-defibrillatormitochondrial DNAperipheral blood mononuclear cellssustained ventricular tachycardia

Identifiers

PMID40160580
PMCPMC11951477

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.