Evidence map›Paper›PMID 40160510›Full record

ArticleHRB open research2025

Economic evaluations  of strategies targeting pre-diagnosis dementia  populations: Protocol for a systematic review.

Men Thi Hoang, Alina Zenker, Sanjib Saha, Ulf-Göran Gerdtham, Dominic Trepel

Abstract read
In one paragraph

Article in HRB open research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Men Thi HoangTrinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Leinster, Ireland.ORCID https://orcid.org/0000-0001-8187-8277
Alina ZenkerSchool of Medicine, Trinity College Dublin, Dublin, Leinster, Ireland.ORCID https://orcid.org/0009-0007-8392-3028
Sanjib SahaHealth Economics Unit, Department of Clinical Science (Malmö), Lund University, Lund, Sweden.
Ulf-Göran GerdthamHealth Economics Unit, Department of Clinical Science (Malmö), Lund University, Lund, Sweden.
Dominic TrepelTrinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Leinster, Ireland.ORCID https://orcid.org/0000-0002-1421-2966

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Dementia remains incurable, and treatment trials are typically conducted after the symptoms manifest, potentially too late in the disease process to alter its course. Thus, it is essential to identify and implement cost-effective strategies targeting individuals who have not yet been formally diagnosed with dementia. This review aims to scrutinise emerging evidence and present a comprehensive summary of cost-effectiveness estimates of all strategies targeting the pre-diagnosis dementia populations. Method and analysis: A systematic search will be conducted across six electronic databases. All articles will be assessed against pre-defined eligibility criteria through title and abstract screening, and full-text screening phases. Data from the included articles will be extracted using a standardized template. A newly established framework based on the CHEERS 2022 checklist will be applied to assess the reporting quality of the included articles. The entire review process, from screening to data extraction and quality assessment, will be a dual process conducted by two reviewers. Disagreements will be resolved by a third senior reviewer. The extracted data will be synthesised and presented in tables and figures. Conclusion: This systematic review will present evidence of cost-effectiveness, along with the strengths and limitations of the existing literature. These findings aim to identify existing gaps, thereby informing and guiding the design of future studies in this domain. Ethics and dissemination: Since this is a systematic review protocol, ethical approval is not required. The results will be published in a peer-reviewed journal, with both raw and summarised data shared through the journal or other open platforms. Systematic review registration: PROSPERO - CRD42024521521.

Indexed as

Alzheimer's DiseaseCost-effectiveness Analysisdementiaeconomic evaluationidentificationtreatment

Identifiers

PMID40160510
PMCPMC11950719

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.