Evidence map›Paper›PMID 40160494›Full record

ArticleJournal of blood medicine2025

Prevalence and Demographic Analysis of Hemoglobinopathies in Newborns: A Three-Year Study at Thumbay Teaching Hospital, Ajman-UAE.

Ayman Hussein Alfeel, Tagwa Yousif Elsayed Yousif, Ammar Abdelmola, Praveen Kumar, Hussam Ali Osman, Rabab Hassan Elshaikh, Muhammad Saboor, Salah Omar Hussein, Elryah I Ali, Izzeldin Elbashir

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Article in Journal of blood medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Ayman Hussein AlfeelDepartment of Medical Laboratory Sciences, College of Health Sciences, Gulf Medical University, Ajman, United Arab Emirates.ORCID 0000-0002-5426-2204
Tagwa Yousif Elsayed YousifDepartment of Medical Laboratory Technology, College of Nursing and Health Sciences, Jazan University, Gizan, Saudi Arabia.ORCID 0000-0002-0238-8083
Ammar AbdelmolaDepartment of Medical Laboratory Technology, College of Nursing and Health Sciences, Jazan University, Gizan, Saudi Arabia.
Praveen KumarDepartment of Medical Laboratory Sciences, College of Health Sciences, Gulf Medical University, Ajman, United Arab Emirates.
Hussam Ali OsmanDepartment of Medical Laboratory Sciences, Faculty of Medical and Health Sciences, Liwa College, Abu Dhabi, United Arab Emirates.ORCID 0000-0002-2017-2331
Rabab Hassan ElshaikhDepartment of Medical Laboratory Sciences, A' Sharqiyah University, Ibra, Oman.
Muhammad SaboorDepartment of Medical Laboratory Sciences, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.ORCID 0000-0002-2901-0216
Salah Omar HusseinDepartment of Medical Laboratory Sciences, College of Health Sciences, Gulf Medical University, Ajman, United Arab Emirates.ORCID 0000-0002-1819-5948
Elryah I AliDepartment of Medical Laboratory Technology, College of Applied Medical Sciences, Northern Border University, Arar, Saudi Arabia.
Izzeldin ElbashirDepartment of Medical Laboratory Sciences, College of Health Sciences, Gulf Medical University, Ajman, United Arab Emirates.ORCID 0000-0001-9720-1535

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Purpose: Hemoglobinopathies are hereditary blood disorders affecting hemoglobin in red blood cells. This study aimed to determine the prevalence and types of hemoglobinopathies among newborns in Thumbay Teaching Hospital, Ajman-UAE, over three years (2020-2022), and to analyze demographic trends. Method and Population: A laboratory-based retrospective cross-sectional study was conducted, involving 6,050 newborns screened using High-Performance Liquid Chromatography (HPLC). Results: We consider this study and its results as a new effort in the field of hemoglobinopathy research and management in Ajman in the United Arab Emirates. The final main findings revealed different hemoglobinopathy cases. In 2020 Two cases (2) involving Hb C variant were recorded, both of African origin (from Sudan and Egypt). The third case was Hb D variant which was also of African origin (Egypt). In 2021 no case was found. In 2022, the results showed a widespread of cases; A patient from Nigeria reported having Hb C, three cases of Hb D from Pakistan, two cases of Hb E trait from people in Bangladesh and India, one case of Hb S from Malawi, five cases of Hb S trait from people in Africa (two from Kenya, one from Tanzania), and two cases from Asian people from Yemen. The total number of detected hemoglobinopathies was 15 cases, accounting for a percentage of (0.2%). Conclusion: The study reveals a diverse presence of hemoglobinopathies among newborns in Ajman and underscores the importance of newborn screening programs to facilitate early diagnosis and treatment, particularly in regions with high genetic disorder prevalence. The study revealed almost an obvious African origin of Hb C and S cases and Asian one of Hb E and D cases.

Indexed as

Hb CHb DHb EHb-S diseasehemoglobinopathyneonatal screeningthalassemia

Identifiers

PMID40160494
PMCPMC11954398

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