ArticleiScience2025
Protein-constrained models pinpoints the role of underground metabolism in robustness of metabolic phenotypes.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- EINN: An enzyme-informed neural network guided by an enzyme-constrained genome-scale metabolic model.Synthetic and systems biotechnology · 2027Article
- Mapping multi-substrate specificity of Arabidopsis aminotransferases.Nature plants · 2025Article
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Authors and funding
4 authors.
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Abstract
Integrating enzyme parameters into constraint-based models have significantly improved the prediction of physiological and molecular traits. To further improve these models, we integrated promiscuous enzyme activities that jointly comprise the so-called underground metabolism by developing the CORAL toolbox, which increases the resolution of modeled enzyme resource allocation. Applying CORAL to a protein-constrained model of
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Registered trials
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