ArticleOpen forum infectious diseases2025
Long-term Sequelae Following Dengue Infection vs SARS-CoV-2 Infection in a Pediatric Population: A Retrospective Cohort Study.
Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Long-term postacute sequelae following SARS-CoV-2 infection in children have been extensively documented. However, while persistence of chronic symptoms following pediatric dengue infection has been documented in small prospective cohorts, population-based studies are limited. We evaluated the risk of multisystemic complications following dengue infection in contrast to that after SARS-CoV-2 infection in a multiethnic pediatric Asian population. Methods: This retrospective population-based cohort study utilized national COVID-19/dengue registries to construct cohorts of Singaporean children aged 1 to 17 years with either laboratory-confirmed dengue infection from 1 January 2017 to 31 October 2022 or confirmed SARS-CoV-2 infection from 1 July 2021 to 31 October 2022. Cox regression was utilized to estimate risks of new-incident cardiovascular, neurologic, gastrointestinal, autoimmune, and respiratory complications, as identified by national health care claims data, at 31 to 300 days after dengue infection vs COVID-19. Risks were reported by 2 measures: adjusted hazard ratio (aHR) and excess burden. Results: This study included 6452 children infected with dengue and 260 749 cases of COVID-19. Among children infected with dengue, there was increased risk of any postacute gastrointestinal sequelae (aHR, 2.98; 95% CI, 1.18-7.18), specifically appendicitis (aHR, 3.50; 95% CI, 1.36-8.99), when compared with children infected with SARS-CoV-2. In contrast to cases of unvaccinated COVID-19, children infected with dengue demonstrated lower risk (aHR, 0.42; 95% CI, .29-.61) and excess burden (-6.50; 95% CI, -9.80 to -3.20) of any sequelae, as well as lower risk of respiratory sequelae (aHR, 0.17; 95% CI, .09-.31). Conclusions: Lower overall risk of postacute complications was observed in children following dengue infection vs COVID-19; however, higher risk of appendicitis was reported 31 to 300 days after dengue infection vs SARS-CoV-2. Public health strategies to mitigate the impact of dengue and COVID-19 in children should consider the possibility of chronic postinfectious sequelae.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.