Evidence map›Paper›PMID 40160316›Full record

ArticleFrontiers in medicine2025

Case Report: Comprehensive management of trichilemmal carcinoma of the lower leg in an elderly patient with comorbidities: a case study on integrated ALA-PDT and surgical excision.

Chan Hu, Xiaojing Liu, Mingshun Wu, Caihe Liao, Yan Zhao, Mingyuan Xu, Yongxian Lai, Guolong Zhang

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chan HuInstitute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China.
Xiaojing LiuInstitute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China.
Mingshun WuInstitute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China.
Caihe LiaoInstitute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China.
Yan ZhaoInstitute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China.
Mingyuan XuDepartment of Dermatopathology, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China.
Yongxian LaiDepartment of Dermatologic Surgery, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China.
Guolong ZhangInstitute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Trichilemmal carcinoma (TC), a rare malignancy originating from hair follicle cells, typically affects sun-exposed skin in older individuals and necessitates differential diagnosis from other skin carcinomas. Here, we present one case of trichilemmal carcinoma in a 92-year-old female, admitted to our hospital with a large exophytic red tumor on her right lower leg. Notably, the patient had a history of long-standing hypothyroidism and hypertension, indicating that she was unable to tolerate extensive excision. Histopathology showed outer root sheath hyperplasia with clear cell differentiation and keratinization, alongside increased atypical cells. Immunohistochemistry revealed CK7 and EMA positivity, confirming follicular origin, while negative CK10, CK18, CEA, CK20, and GCDFP-15 excluded other follicular tumors. A high Ki-67 (80%) indicated high proliferative activity, supporting the TC diagnosis. Treatment involved managing her underlying conditions, followed by ALA-PDT and surgical excision for the carcinoma. This case illustrates the challenges in managing trichilemmal carcinoma in elderly patients with multiple comorbidities, emphasizing the importance of a comprehensive approach to treatment.

Indexed as

ALA-PDTdermatologyimmunomodulatorysurgical resectiontrichilemmal carcinoma

Identifiers

PMID40160316
PMCPMC11949778

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.