Evidence map›Paper›PMID 40160247›Full record

ArticleMaterials today. Bio2025

Engineering exosome membrane disguised thermal responsive system for targeted drug delivery and controlled release across the blood-brain barrier.

Zhe Han, Haina Huang, Boyan Li, RongRong Zhao, Qingtong Wang, Hong Liu, Hao Xue, Weijia Zhou, Gang Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhe HanDepartment of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Ji'nan, Shandong, 250012, China.
Haina HuangInstitute for Advanced Interdisciplinary Research (iAIR), School of Chemistry and Chemical Engineering, University of Jinan, Ji'nan, 250022, China.
Boyan LiDepartment of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Ji'nan, Shandong, 250012, China.
RongRong ZhaoDepartment of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Ji'nan, Shandong, 250012, China.
Qingtong WangDepartment of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Ji'nan, Shandong, 250012, China.
Hong LiuInstitute for Advanced Interdisciplinary Research (iAIR), School of Chemistry and Chemical Engineering, University of Jinan, Ji'nan, 250022, China.
Hao XueDepartment of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Ji'nan, Shandong, 250012, China.
Weijia ZhouInstitute for Advanced Interdisciplinary Research (iAIR), School of Chemistry and Chemical Engineering, University of Jinan, Ji'nan, 250022, China.
Gang LiDepartment of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Ji'nan, Shandong, 250012, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The blood-brain barrier (BBB) presents a significant challenge for the delivery of chemotherapy drugs to brain tumors, leading to ineffective drug concentrations at the tumor site and contributing to chemotherapy resistance. The hypoxic tumor microenvironment further complicates this process, ultimately resulting in poor patient prognosis. In this study, we developed a thermoresponsive nanocarrier system that incorporates (Ru)(Pt) bimetallic nanoparticles onto defective TiOx nanoparticles with abundant oxygen vacancies, generating composite Ru/Pt-TiOx nanoparticles with photothermal and photocatalytic properties. The Ru and Pt in the nanoparticles enhance the metal-carrier interactions, with Ru increasing both light absorption and photothermal conversion efficiency and Pt catalyzing the conversion of endogenous H

Indexed as

Exosome membrane camouflageGlioblastomaMultimodal synergistic therapyPenetrating the blood‒brain barrierThermoresponsive nanocarrier system

Identifiers

PMID40160247
PMCPMC11953974

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.