ArticleJournal of cosmetic dermatology2025
Determination via an Integration Strategy of the Potential Dermal ECM Reconstruction Mechanism by Which the WAW Formula Alleviates Skin Aging.
Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Traditional Chinese Medicine Formulas in Delaying Aging: From Theoretical Foundations to Molecular Mechanisms and Translational Perspectives.Journal of cellular and molecular medicine · 2026Review
- Molecular mechanisms of traditional Chinese medicine in skin aging: a narrative review.Frontiers in pharmacology · 2026Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundTraditional Chinese medicine (TCM) treats skin conditions and delays aging using specific formulas. TCM links skin health to internal organ functions: kidney qi deficiency accelerates aging, whereas spleen deficiency leads to dry, loose skin from insufficient qi and blood. The renowned spleen-tonifying and kidney-nourishing formula "Wan An Wan" moisturizes the skin, but its antiageing mechanism remains unclear.
aimsThe aim of this study was to investigate the development strategy and comprehensive methodological framework for incorporating TCM into cosmetics and to assess the mechanism of action and application potential of the WAW formula in mitigating skin aging.
resultsIn vitro experiments revealed that after optimizing the extraction of the active ingredients of the tailored WAW formula, it effectively inhibited NO production and tyrosinase activity and increased filaggrin, AQP, and HAS2 mRNA expression. Moreover, the active ingredients, including morroniside, were also analyzed separately. Mechanistic studies revealed that the tailored WAW formula upregulated the expression of the TGF-β1 gene associated with ECM production and downregulated the expression of the MMP-2/MMP-9 genes associated with ECM degradation, regulating cell behaviors such as migration, adhesion, and proliferation and thereby maintaining the healthy state of the skin.
conclusionsIn this study, an overall strategy for applying TCM for the development of skin care solutions was established, the potential value of WAW in modern dermatologic applications was revealed, innovative raw materials with comprehensive effects were developed, and new ideas for the fields of cosmetics and dermatology were provided.
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