Evidence map›Paper›PMID 40159977›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2025

[High MYO1B expression promotes proliferation, migration and invasion of gastric cancer cells and is associated with poor patient prognosis].

Qingqing Huang, Wenjing Zhang, Xiaofeng Zhang, Lian Wang, Xue Song, Zhijun Geng, Lugen Zuo, Yueyue Wang, Jing Li, Jianguo Hu

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
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Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Qingqing HuangClinical Laboratory, the First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
Wenjing ZhangClinical Laboratory, the First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
Xiaofeng ZhangClinical Laboratory, the First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
Lian WangDepartment of Gastrointestinal surgery, the First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
Xue SongCentral Laboratory, the First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
Zhijun GengCentral Laboratory, the First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
Lugen ZuoDepartment of Gastrointestinal surgery, the First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
Yueyue WangClinical Laboratory, the First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
Jing LiClinical Laboratory, the First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
Jianguo HuClinical Laboratory, the First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo analyze MYO1B expression in gastric cancer, its association with long-term prognosis and its role in regulating biological behaviors of gastric cancer cells.

methodsWe analyzed MYO1B expression in gastric cancer and its correlation with tumor grade, tumor stage, and patient survival using the Cancer Public Database. We also examined MYO1B expression with immunohistochemistry in gastric cancer and paired adjacent tissues from 105 patients receiving radical surgery and analyzed its correlation with cancer progression and postoperative 5-year survival of the patients. GO and KEGG enrichment analyses were used to explore the biological functions of MYO1B and the key pathways. In cultured gastric cancer cells, we examined the changes in cell proliferation, migration and invasion following MYO1B overexpression and knockdown.

resultsData from the Cancer Public Database showed that MYO1B expression was significantly higher in gastric cancer tissues than in normal tissues with strong correlations with tumor grade, stage and patient prognosis (

conclusionsHigh MYO1B expression promotes proliferation, migration and invasion of gastric cancer cells and is correlated with poor patient prognosis.

Indexed as

Myosin Type IStomach NeoplasmsCell Line, TumorCell MovementCell ProliferationFemaleHumansMaleNeoplasm InvasivenessPrognosisMYO1B protein, humanMyosin Type Igastric cancerMYO1Bprognosisproliferation

Identifiers

PMID40159977
PMCPMC11955900

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