ArticleThe Korean journal of pain2025
Neuroplasticity in chronic pain: insights into diagnosis and treatment.
Article in The Korean journal of pain, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Alterations in white matter integrity in patients with postherpetic neuralgia evidenced by peak width of skeletonized mean diffusivity analysis.The Korean journal of pain · 2026Article
- Dynamic reconfiguration of directed effective connectivity between attention networks and the default mode network in knee osteoarthritis: a combined resting-state and non-noxious thermal stimulation functional magnetic resonance imaging study.The Korean journal of pain · 2026Article
- Brain morphometric alterations associated with degenerative scoliosis: a structural MRI study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Review
- Reliability of Electrical Threshold Testing for Assessing Sensory, Motor and Pain Thresholds: An Exploratory Study in Active Subjects.Journal of functional morphology and kinesiology · 2026Article
- Dynamic coupling of emotion and pain: from perception to affective response.The Korean journal of pain · 2026Review
- Altered Brain Functional Connectivity in Postherpetic Neuralgia and Its Association With Neuropathic Pain.Journal of clinical neurology (Seoul, Korea) · 2026Article
- Transcriptional correlates of structure-function coupling plasticity in trigeminal neuralgia: unveiling the synaptic and metabolic associations.The journal of headache and pain · 2026Article
- Sustained Attention Instability as a Cognitive Biomarker in Chronic Spine Pain: A 90-second Visual Attention Test.European journal of pain (London, England) · 2026Article
- Altered Structural Brain Connectivity in Postherpetic Neuralgia and its Association with Neuropathic Pain Severity: A Diffusion Tensor Imaging Study.Brain topography · 2026Article
- Concordance of cortical morphological anomalies with genetic predisposition to multisite chronic pain in females.The Korean journal of pain · 2026Article
- Toward a global paradigm shift: integrating neuroplasticity, cultural sensitivity, and scalable interventions in chronic pain.The Korean journal of pain · 2026Article
- Gastrodin alleviates bortezomib-induced peripheral neuropathy by inhibiting NF-κB/NLRP3 pathway-mediated microglial inflammation.The Korean journal of pain · 2026Article
- Musculoskeletal Pain During Late Adolescence: The Generation R Study.European journal of pain (London, England) · 2026Article
- Neuroimaging-Guided Insights into the Molecular and Network Mechanisms of Chronic Pain and Neuromodulation.International journal of molecular sciences · 2026Review
- Electroacupuncture improves psychosocial outcomes in rectal cancer patients with bowel dysfunction.World journal of psychiatry · 2026Article
- Targeting N-methyl-D-aspartate 2B receptor in painful diabetic neuropathy - mechanisms, challenges, and emerging therapeutics.World journal of diabetes · 2026Review
- Article
- The Translational Biology of Temporomandibular Disorder Pain: Mechanisms, Biomarkers, and Therapeutic Perspectives.Journal of pain research · 2026Review
- Chronic pain as a brain disease: bridging neuroscience and global health.The Korean journal of pain · 2026Article
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Authors and funding
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Abstract
Chronic pain is a universal problem that directly evolves the central nervous system, altering both its structure and function. This review discusses neuroplastic alterations in critical areas in the brain like the anterior cingulate cortex, insula, prefrontal cortex, primary (S1) and secondary (S2) somatosensory cortices, and thalamus. These regions exhibit gray matter decrease and changes in connectivity during chronic pain. Several cortical networks, mainly the central executive network, the default mode network, and the salience network exhibit neuroplasticity which reallocates cognitive and emotional resources to pain processing. Thus, it was reported that sensitivity to pain enhances emotional suffering, indicating that altered connectivity and functional reorganization of these networks support maladaptive pain processing and underpin chronic pain persistence. Neuroplasticity-focused treatments such as brain stimulation, neuro-feedback, and exercise-based therapies constitute potential interventions for preventing such negative changes. Further, innovative neuroimaging biomarkers are effective in demonstrating precise neural changes and in providing information about the diagnosis of chronic pain syndromes. This review highlights neuro-plastic changes in chronically painful patients and acknowledges the brain's plasticity as a target for chronic pain treatment. It, also, points to the diagnostic strategies and practical interventions that address these alterations.
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