Evidence map›Paper›PMID 40159838›Full record

ReviewJournal of gastroenterology and hepatology2025

Role of Endoscopy in Clinical Management of Intraductal Papillary Mucinous Neoplasms.

Tsuyoshi Hamada, Hiroki Oyama, Naminatsu Takahara, Yousuke Nakai, Mitsuhiro Fujishiro

Abstract readReview
In one paragraph

Review in Journal of gastroenterology and hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tsuyoshi HamadaGraduate School of Medicine, Department of Gastroenterology, The University of Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0002-3937-2755
Hiroki OyamaGraduate School of Medicine, Department of Gastroenterology, The University of Tokyo, Tokyo, Japan.
Naminatsu TakaharaGraduate School of Medicine, Department of Gastroenterology, The University of Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0002-1265-3100
Yousuke NakaiGraduate School of Medicine, Department of Gastroenterology, The University of Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0001-7411-1385
Mitsuhiro FujishiroGraduate School of Medicine, Department of Gastroenterology, The University of Tokyo, Tokyo, Japan.

Funding

Daiichi Sankyo CompanyJapan Society for the Promotion of Science (JSPS) KAKENHI JP22H02841Japan Society for the Promotion of Science (JSPS) KAKENHI JP24K18903Practical Research for Innovative Cancer Control Program from Japan Agency for Medical Research and Development 23ck0106807Takeda Science Foundation
6 · The paper itself

Abstract

Intraductal papillary mucinous neoplasm (IPMN) of the pancreas is a well-recognized precursor of pancreatic carcinoma. Along with cross-sectional abdominal imaging tests, endoscopic examinations remain the cornerstone in the diagnosis of pancreatic cysts, early detection of IPMN-derived carcinomas, and risk stratification of patients with IPMNs for subsequent surveillance strategies. In particular, endoscopic ultrasound (EUS) facilitates the optimal patient management by providing high-resolution morphological information, and the contrast-enhanced harmonic mode may further enhance diagnostic accuracy. EUS-guided fine-needle aspiration for solid mass and/or cyst fluid is considered for pathological and molecular examinations for the diagnosis of pancreatic cysts and malignancy. Emerging evidence suggests the usefulness of through-the-needle biopsy and confocal laser microendoscopy in this setting. In addition to the undoubtful diagnostic utility, recent studies have demonstrated the potential effect of endoscopic interventions (i.e., ablation) on the control of IPMNs. Despite the increasing role of endoscopy in the clinical management of IPMNs, there remains a gap in our understanding of how to utilize endoscopy in the personalized care for patients with IPMNs (e.g., the optimal interval of EUS) and the prevention of deaths due to pancreatic carcinomas developing concomitantly with IPMNs. This review summarizes the current evidence on the role of endoscopy in both the diagnostic and therapeutic landscapes of clinical management of IPMNs and identifies key clinical unmet needs that should be addressed in future research. Combined with emerging technologies (e.g., artificial intelligence and high-throughput molecular profiling), endoscopy would offer more effective and tailored management strategies for patients with IPMNs.

Indexed as

Adenocarcinoma, MucinousCarcinoma, Pancreatic DuctalPancreatic Intraductal NeoplasmsPancreatic NeoplasmsEndoscopic Ultrasound-Guided Fine Needle AspirationEndosonographyHumansPancreatic Cystendoscopic retrograde cholangiopancreatographyendosonographypancreatic cystpancreatic neoplasmsrisk factors

Identifiers

PMID40159838
PMCPMC12062927

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.