Evidence map›Paper›PMID 40159572›Full record

ArticleInternational journal of hematology2025

Persistent neonatal alloimmune thrombocytopenia caused by triple anti-HLA-A11, -B3901, and -Cw7 antibodies.

Shiho Hatano, Hajime Maeda, Hirotaka Ichikawa, Kei Ogasawara, Nozomi Takano, Shunya Rikimaru, Kinuyo Kawabata, Kazuhiko Ikeda, Hitoshi Ohto, Hayato Go

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Article in International journal of hematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shiho HatanoDepartment of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan.
Hajime MaedaDepartment of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan. hmaeda@fmu.ac.jp.ORCID http://orcid.org/0000-0003-2328-6577
Hirotaka IchikawaDepartment of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan.
Kei OgasawaraDepartment of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan.
Nozomi TakanoDepartment of Blood Transfusion and Transplantation Immunology, Fukushima Medical University School of Medicine, Fukushima, Japan.
Shunya RikimaruDepartment of Blood Transfusion and Transplantation Immunology, Fukushima Medical University School of Medicine, Fukushima, Japan.
Kinuyo KawabataDepartment of Blood Transfusion and Transplantation Immunology, Fukushima Medical University School of Medicine, Fukushima, Japan.
Kazuhiko IkedaDepartment of Blood Transfusion and Transplantation Immunology, Fukushima Medical University School of Medicine, Fukushima, Japan.
Hitoshi OhtoFukushima Medical University, Fukushima, Japan.
Hayato GoDepartment of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFetal and neonatal alloimmune thrombocytopenia (FNAIT) is primarily caused by the transplacental passage of maternal antibodies commonly directed against fetal human platelet antigens (HPA) and rarely against human leukocyte antigens (HLA). STUDY DESIGN AND

methodsHere, we report a case of prolonged neonatal alloimmune thrombocytopenia (NAIT) associated with three anti-HLA antibodies. A male infant was delivered at 37 weeks' gestation because of non-reassuring fetal status. His platelet count decreased to 14 × 10

resultsAnti-HLA-A11, -B3901, and -Cw7 antibodies, but not anti-HPA antibodies, were identified in the mother's blood that reacted with the lymphocytes of the infant and his father.

conclusionThree distinct anti-HLA (HLA-A11, B3901, and Cw7) may have caused the prolonged neonatal thrombocytopenia observed in the present case. This case report demonstrates the role of anti-HLA antibodies in the pathogenesis of FNAIT.

Indexed as

HLA-A AntigensHLA-C AntigensIsoantibodiesThrombocytopenia, Neonatal AlloimmuneAdultFemaleHumansImmunoglobulins, IntravenousInfant, NewbornMalePlatelet TransfusionPregnancyHLA-A AntigensHLA-C AntigensImmunoglobulins, IntravenousIsoantibodiesHuman leukocyte antigenHuman platelet antigenMultiple alloantibodiesNeonatal alloimmune thrombocytopenia

Identifiers

PMID40159572

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