Evidence map›Paper›PMID 40159555›Full record

ArticleBiogerontology2025

Elucidating the role of peripheral monocyte nicotinic acetylcholine receptors and inflammation in cognitive outcomes in older adults.

Jordan N Kohn, Gavrila Ang, Christopher Pruitt, Isabel Gandarilla, Xin Tu, Suzi Hong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biogerontology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jordan N KohnHerbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, 9500 Gilman Dr., #0804, La Jolla, CA, 92093, USA. jokohn@health.ucsd.edu.ORCID 0000-0001-8546-2076
Gavrila AngDepartment of Psychiatry, University of California San Diego, La Jolla, CA, 92093, USA.
Christopher PruittHerbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, 9500 Gilman Dr., #0804, La Jolla, CA, 92093, USA.
Isabel GandarillaHerbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, 9500 Gilman Dr., #0804, La Jolla, CA, 92093, USA.
Xin TuHerbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, 9500 Gilman Dr., #0804, La Jolla, CA, 92093, USA.
Suzi HongHerbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, 9500 Gilman Dr., #0804, La Jolla, CA, 92093, USA.

Funding

Autonomic and Immuno-vascular Mechanisms of Antihypertensive Effects of TaichiR01HL126056 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HONG, SUZI, REDWINE, LAURA S · 2015 to 2019
$3.6M
Multisystem risk profile of older adults to predict cognitive function and impairmentR03AG063328 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HONG, SUZI · 2019 to 2021
$472k
NHLBI NIH HHS R01 HL126056NHLBI NIH HHS R01HL126056NIA NIH HHS R03 AG063328NIA NIH HHS R03AG063328
6 · The paper itself

Abstract

Nicotinic acetylcholine receptors (nAChRs) are important regulators of brain and immune function that play critical roles in the neuropathology and progression of Alzheimer's disease and related dementias (ADRD). However, quantifying nAChRs in the brain remains elusive, and little is known about peripheral measures of nAChR in older adults or their relationship to cognition. Here, we examined associations between nAChR expression and immunoregulatory function in peripheral blood monocytes and cognitive performance among 167 older adults (age 72.3 ± 7.6 years; 71% female). Penalized linear and logistic regression were used to identify nAChR-related features in classical, intermediate, and nonclassical monocytes, as well as immunophenotypes, clinical and sociodemographic factors, associated with cognitive status (Montreal Cognitive Assessment; MoCA). Intermediate monocytes had the highest expression of alpha-7 nAChRs and greater ex vivo inflammatory responses (83.7% TNF-ɑ

Indexed as

CognitionCognitive DysfunctionInflammationMonocytesReceptors, NicotinicAgedAged, 80 and overFemaleHumansMaleReceptors, NicotinicAcetylcholine receptorsAnticholinergic burdenCognitionImmune agingMonocytes

Identifiers

PMID40159555
PMCPMC11955431

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.