Evidence map›Paper›PMID 40159552›Full record

ArticleAnnals of surgical oncology2025

Pre-existing Mental Health Disorders are Associated with Disparities in Gastric Cancer Care: An American Combined Safety Net and Teaching Hospital Experience.

Morgan F Pettigrew, Andres A Abreu, Amr I Al Abbas, John D Karalis, Rodrigo E Alterio, Cecilia G Ethun, Patricio M Polanco, John C Mansour, Adam C Yopp, Herbert J Zeh and 2 more

Abstract read
In one paragraph

Article in Annals of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Morgan F Pettigrew *Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Andres A Abreu *Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Amr I Al AbbasDivision of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
John D KaralisDivision of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Rodrigo E AlterioDivision of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Cecilia G EthunDivision of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Patricio M PolancoDivision of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
John C MansourDivision of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Adam C YoppDivision of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Herbert J ZehDivision of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Sam C WangDivision of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Matthew R PorembkaDivision of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA. matthew.porembka@utsouthwestern.edu.ORCID http://orcid.org/0000-0003-1596-0058

Funding

Determining the role of germline CDH1 variants in gastric cancer outcome disparities in Hispanic/Latino patientsR37CA265967 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Sam C. Wang · 2022 to 2026
$3.6M
Using artificial intelligence to discover spatial, genomic, and pathologic biomarkers to guide and augment immune checkpoint inhibitor therapy for gastric cancerR01CA276690 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Tae Hyun Hwang, Sam C. Wang · 2024 to 2026
$2.0M
American College of Surgeons Research Resident ScholarshipNCI NIH HHS R01 CA276690NCI NIH HHS R01CA276690NCI NIH HHS R37 CA265967NCI NIH HHS R37CA265967
6 · The paper itself

Abstract

introductionDelay in gastric cancer diagnosis is associated with inferior outcomes. The effects of pre-existing mental health disorders (MHDs) on delays in gastric cancer diagnosis and treatment disparities are not well-understood. In this study, we evaluated the impact of MHDs on time to gastric cancer diagnosis and receipt of guideline-concordant treatment.

methodsWe performed a retrospective review of patients diagnosed with gastric adenocarcinoma between 2015 and 2022. Patients with pre-existing diagnoses of mood, affective, and substance use disorders were classified as having an MHD. Univariable and multivariable regression were used to analyze the association between MHDs and delay in diagnosis. The association between MHD and receipt of guideline-concordant care was also evaluated.

resultsOverall, 460 patients diagnosed with gastric cancer were included in the analytic group. Seventy patients (15%) had an MHD prior to their cancer diagnosis, of whom 34 (49%) experienced a delay in diagnosis, compared with 109 (28%) without an MHD. On multivariable regression, patients with an MHD were more likely to experience a delay in diagnosis (odds ratio [OR] 2.84, 95% confidence interval [CI] 1.58-5.11; p < 0.001) and have more than one visit to a provider prior to diagnosis (OR 2.71, 95% CI 1.37-5.37; p = 0.004). Patients with an MHD were also less likely to receive guideline-concordant care for their gastric cancer (OR 0.29, 95% CI 0.12-0.67; p = 0.004).

conclusionsMHD is a patient-level factor that negatively impacts gastric cancer care. Addressing provider knowledge gaps and increasing efforts to counter the social stigma and implicit bias associated with MHD may improve the time to diagnosis and receipt of guideline-concordant care in this at-risk population.

Indexed as

AdenocarcinomaDelayed DiagnosisHealthcare DisparitiesHospitals, TeachingMental DisordersSafety-net ProvidersStomach NeoplasmsAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisRetrospective StudiesUnited States

Identifiers

PMID40159552
PMCPMC13014627

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.