Evidence map›Paper›PMID 40159523›Full record

Observational studyNeurosurgical review2025

The association between neutrophil to lymphocyte ratio and covert brain infarction after carotid endarterectomy: a single center retrospective study.

Yunfeng Han, Xuan Lai, Hua Zhang, Jun Yang, Tao Wang

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Neurosurgical review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yunfeng Han *Department of Neurosurgery, Peking University Third Hospital, Beijing, 100191, China.
Xuan Lai *Department of Geriatrics, Peking University Third Hospital, Beijing, 100191, China.
Hua ZhangResearch Centre of Clinical Epidemiology, Peking University Third Hospital, Beijing, 100191, China.
Jun YangDepartment of Neurosurgery, Peking University Third Hospital, Beijing, 100191, China.
Tao WangDepartment of Neurosurgery, Peking University Third Hospital, Beijing, 100191, China. wangtao@bjmu.edu.cn.

Funding

National Natural Science Foundation of China 82071308National Natural Science Foundation of China 82201635Peking University Third Hospital BYSYFY 2021044
6 · The paper itself

Abstract

backgroundNeutrophil to lymphocyte ratio (NLR) is a biomarker which is related with inflammation and atherosclerosis. Higher NLR is associated with vulnerability of carotid atherosclerotic plaques. Covert brain infarction (CBI) following carotid endarterectomy (CEA) indicates poor prognosis in cognization. In this study, we aimed to investigate the relationship between NLR and CBI in patients who accepted CEA.

methodsIn this observational and retrospective cohort study, 333 patients who underwent CEA due to severe carotid artery stenosis were enrolled. NLR was acquired from routine blood tests upon admission. Postoperative CBI was detected on magnetic resonance imaging. Logistic regression analysis was used to examine the association between NLR and CBI.

resultsPatients with CBI had higher NLR (CBI patients: 2.45[1.76-3.58] vs. non-CBI patients: 2.31[1.82-2.88]; P = 0.05). NLR is a strong independent factor predicting the risk of CBI following CEA (odds ratio [OR], 1.740; 95% confidence interval [CI]: 1.325-2.286; P < 0.001). Furthermore, the predictive risk value by NLR is not affected by other related factors.

conclusionsNLR is associated with the risk of CBI in patients underwent CEA. NLR is a convenient and low-cost biomarker that can be used for risk stratification management of perioperative carotid stenosis patients.

Indexed as

Brain InfarctionCarotid StenosisEndarterectomy, CarotidLymphocytesNeutrophilsPostoperative ComplicationsAgedAged, 80 and overBiomarkersFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsBiomarkersCarotid endarterectomyCovert brain infarctionNeutrophil to lymphocyte ratio

Identifiers

PMID40159523

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.