Evidence map›Paper›PMID 40159488›Full record

ArticleCell communication and signaling : CCS2025

NEDD4 E3 ligase-catalyzed NAMPT ubiquitination and autophagy activation are essential for pyroptosis-independent NAMPT secretion in human monocytes.

Marisela Rodriguez, Haifei Xu, Annie Hernandez, Julia Ingraham, Jason Canizales, Fernando Teran Arce, Sara M Camp, Skyler Briggs, Aikseng Ooi, James M Burke and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell communication and signaling : CCS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Marisela RodriguezCenter for Inflammation Science and Systems Medicine, University of Florida Scripps Research Institute, Jupiter, FL, 33458, USA.
Haifei XuCenter for Inflammation Science and Systems Medicine, University of Florida Scripps Research Institute, Jupiter, FL, 33458, USA.
Annie HernandezCenter for Inflammation Science and Systems Medicine, University of Florida Scripps Research Institute, Jupiter, FL, 33458, USA.
Julia IngrahamCenter for Inflammation Science and Systems Medicine, University of Florida Scripps Research Institute, Jupiter, FL, 33458, USA.
Jason CanizalesCenter for Inflammation Science and Systems Medicine, University of Florida Scripps Research Institute, Jupiter, FL, 33458, USA.
Fernando Teran ArceCenter for Inflammation Science and Systems Medicine, University of Florida Scripps Research Institute, Jupiter, FL, 33458, USA.
Sara M CampCenter for Inflammation Science and Systems Medicine, University of Florida Scripps Research Institute, Jupiter, FL, 33458, USA.
Skyler BriggsDepartment of Molecular Medicine, University of Florida Scripps Research Institute, Jupiter, FL, USA.
Aikseng OoiCenter for Inflammation Science and Systems Medicine, University of Florida Scripps Research Institute, Jupiter, FL, 33458, USA.
James M BurkeDepartment of Molecular Medicine, University of Florida Scripps Research Institute, Jupiter, FL, USA.
Jin H Song *Center for Inflammation Science and Systems Medicine, University of Florida Scripps Research Institute, Jupiter, FL, 33458, USA.
Joe G N Garcia *Center for Inflammation Science and Systems Medicine, University of Florida Scripps Research Institute, Jupiter, FL, 33458, USA. jgn.garcia@ufl.edu.

Funding

Structure-Function Analysis of nmMLCK in EC Barrier ResponsesP01HL126609 · NHLBI · UNIVERSITY OF FLORIDA · PI Saad Sammani · 2016 to 2026
$24.4M
Novel Involvement of NAMPT and TLR4 in PAH Vascular RemodelingR01HL141387 · NHLBI · UNIVERSITY OF FLORIDA · PI Joe G. N. Garcia, Ayako Makino · 2019 to 2026
$3.8M
Understanding the OAS/RNase L pathway during pathogenic viral infectionsR35GM151249 · NIGMS · UNIVERSITY OF FLORIDA · PI James M Burke · 2023 to 2026
$1.9M
Novel mechanism for eNAMPT secretion in PAH vascular remodelingF31AG082409 · NIA · UNIVERSITY OF FLORIDA · PI RODRIGUEZ, MARISELA · 2023 to 2024
$82k
NHLBI NIH HHS P01 HL126609NHLBI NIH HHS R01 HL141387NIGMS NIH HHS R35 GM151249NIH HHS F31 AG082409NIH HHS R35 GM151249
6 · The paper itself

Abstract

NAMPT is an important intracellular metabolic enzyme (iNAMPT) regulating the NAD

Indexed as

AutophagyCytokinesMonocytesNedd4 Ubiquitin Protein LigasesNicotinamide PhosphoribosyltransferasePyroptosisUbiquitinationHumansInflammasomesLipopolysaccharidesNLR Family, Pyrin Domain-Containing 3 ProteinTHP-1 CellsCytokinesInflammasomesLipopolysaccharidesNedd4 Ubiquitin Protein LigasesNicotinamide Phosphoribosyltransferasenicotinamide phosphoribosyltransferase, humanNLR Family, Pyrin Domain-Containing 3 ProteinAutophagyDAMPeNAMPTGasdermin DNLRP3 inflammasomePyroptosisUbiquitination

Identifiers

PMID40159488
PMCPMC11956250

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.