Evidence map›Paper›PMID 40159462›Full record

ArticleClinical and translational medicine2025

The FBP1-TP53-NRF2 metabolic switch in metabolic dysfunction-associated steatohepatitis-hepatocellular carcinoma progression and senescence reversal.

Yahui Zhu, Donglin Wei, Michael Karin, Li Gu

Abstract readLetter
In one paragraph

Article in Clinical and translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yahui ZhuSchool of Medicine, Chongqing University, Chongqing, China.
Donglin WeiSchool of Medicine, Chongqing University, Chongqing, China.ORCID https://orcid.org/0009-0008-3672-5130
Michael KarinDepartments of Pharmacology and Pathology, Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California San Diego (UCSD), La Jolla, California, USA.
Li GuDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.ORCID https://orcid.org/0000-0001-5812-9024

Funding

Role of hypernutrition and metabolic stress in non-alcoholic steatohepatitis (NASH) driven hepatocellular carcinoma (HCC)P01CA281819 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI Michael Karin · 2024 to 2026
$9.2M
The NRF2-FBP1 crossregulatory loop and the control of healthy and diseased liver metabolismR01DK133448 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Michael Karin, Jun Hee Lee · 2022 to 2026
$3.6M
A new mouse model for studying the pathogenesis and immunobiology of intrahepatic cholangiocarcinoma and improving its immunotherapyR01CA281784 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Michael Karin · 2023 to 2026
$2.5M
National Natural Science Foundation of China 32470830National Natural Science Foundation of China 82172990National Natural Science Foundation of China 82372838National Natural Science Foundation of China 92478135NCI NIH HHS P01 CA281819NCI NIH HHS R01 CA281784NIDDK NIH HHS R01 DK133448NIH HHS P01CA281819NIH HHS R01CA281784NIH HHS R01DK133448
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID40159462
PMCPMC11955276

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.