Evidence map›Paper›PMID 40159324›Full record

Trial reportFamily process2025

Preliminary Effectiveness of Family Therapy for Perinatal Depressive Symptoms: Results From a Pilot Randomized Trial.

Fallon Cluxton-Keller, Haiyi Xie, Mark T Hegel, Craig L Donnelly, Martha L Bruce

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Family process, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04741776 (A Pilot Randomized Trial of Video-based Family Therapy for Home Visited Mothers With Perinatal Depressive Symptoms), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04741776 nacompletednot on this map

A Pilot Randomized Trial of Video-based Family Therapy for Home Visited Mothers With Perinatal Depressive Symptoms

TypeinterventionalSponsorDartmouth-Hitchcock Medical CenterRan2021 to 2023Enrolled166ConditionsPerinatal Depression, Postpartum Depression, Family ConflictArmsResilience Enhancement Skills Training, Problem-Solving Individual Therapy
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fallon Cluxton-KellerDepartment of Psychiatry, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.ORCID https://orcid.org/0000-0002-8701-1209
Haiyi XieDepartment of Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.ORCID https://orcid.org/0000-0003-4549-879X
Mark T HegelDepartment of Psychiatry, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.ORCID https://orcid.org/0000-0003-2877-2398
Craig L DonnellyDepartment of Psychiatry, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.ORCID https://orcid.org/0000-0002-8762-9893
Martha L BruceDepartment of Psychiatry, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.ORCID https://orcid.org/0000-0002-9973-2142

Funding

A pilot randomized trial of video-based family therapy for home-visited mothers with perinatal depressive symptomsR34MH124951 · NIMH · DARTMOUTH-HITCHCOCK CLINIC · PI CLUXTON-KELLER, FALLON P · 2021 to 2023
$708k
NIMH NIH HHS R34 MH124951
6 · The paper itself

Abstract

A significant portion of mothers (pregnant and postpartum) enrolled in U.S. home visiting programs report clinically significant depressive symptoms. Non-violent family conflict precipitates and exacerbates their depressive symptoms. This pilot randomized trial tested the preliminary effectiveness of a family therapy intervention, Resilience Enhancement Skills Training (REST), compared to the standard of care in home-visited mothers with moderate to severe depressive symptoms and moderate to high conflict with family members. A total of 83 mothers and their family members (N = 166) were randomized to receive REST or the standard of care. Both interventions were delivered by clinicians using HIPAA-compliant video conferencing technology. Outcomes were assessed by research assistants, blinded to study group assignment, at post-intervention, 3, and 6 months later. Linear mixed-effects models were used to analyze changes in continuous outcomes in mothers and family members, separately. Mixed-effects logistic regression was used to analyze changes in maternal job attainment/school enrollment. Participants in both study groups showed improvements in outcomes. When compared to standard-of-care participants, REST participants had significantly greater reductions in family conflict (mothers ES = -1.19, family members ES = -0.77), maternal depressive symptoms (ES = -0.96) and co-occurring anxiety symptoms (ES = -0.59), and greater increases in family cohesion (mothers ES = 0.99, family members ES = 0.94) and maternal job attainment/school enrollment (ES = 0.70). The results highlight the value of family therapy for the treatment of moderate to severe depressive symptoms in home-visited mothers, including those with co-occurring moderate to severe anxiety symptoms. Trial Registration: Registered in ClinicalTrials.gov on 02/04/2021. NCT04741776 https://clinicaltrials.gov/ct2/show/NCT04741776.

Indexed as

DepressionDepression, PostpartumFamily TherapyMothersAdultFamily ConflictFemaleHouse CallsHumansPilot ProjectsPregnancyTreatment OutcomeYoung Adultfamily conflictfamily therapyperinatal depressionpsychotherapy

Identifiers

PMID40159324
PMCPMC11960819

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.